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Articles by Ronok Zahan
Total Records ( 5 ) for Ronok Zahan
  M. Saiful Islam , M. Badrul Alam , Ronok Zahan , G.C. Sarker , N.S. Chowdhury , M. Maruf Khan , Mahedi Hasan , M. Saifur Rahman , M.A. Mosaddik , Mele Jesmin and M. Ekramul Haque
  The present study was designed to investigate the antioxidant and anti neoplastic activities of Ocimum sanctum Linn. (OS) leaves. Antioxidant potential of the OS extract was evaluated in vitro by DPPH (1, 1diphenyl-2-picrylhydrazyl) and NO (Nitric Oxide) scavenging assay and reducing power assay method. OS extract showed prominent scavenging activity in all the methods with IC50 value of 16.39±0.31 and 16.20±0.33 μg mL-1 for DPPH and NO assay method, respectively. In reducing power assay, OS extract also showed significant (p<0.001) activity. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. The anti neoplastic effect of the leaves of OS against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 50 mg kg-1 body weight intraperitoneally. Significant (p<0.001) increases of survival times 33±1.81 days for crude extract of the (50 mg kg-1) treated tumor bearing mice were confirmed with respect to the control group (20±0.12 days). Hematological studies reveal that the Heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant antioxidant as well as anti neoplastic activity.
  Ronok Zahan , M. Badrul Alam , M. Saiful Islam , Gopal C. Sarker , Nargis S. Chowdhury , Salman B. Hosain , M.A. Mosaddik , Mele Jesmin and M. Ekramul Haque
  The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg-1 body weight intraperitoneally. Extract/fractions was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Significant (p<0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg-1) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). The extract/fraction also decreased the body weight of the EAC tumor bearing mice. Hematological studies reveal that the heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant anticancer activity and that is comparable to that of Bleomycin.
  M. Badrul Alam , M. Sarowar Hossain , N. Sultana Chowdhury , M. Asadujjaman , Ronok Zahan , M. Monirul Islam , M. Ehsanul Haque Mazumder , M. Ekramul Haque and Anwarul Islam
  The present study was designed to investigate the antioxidant, anti-inflammatory and antipyretic potential of the methanolic extract along with its organic soluble fractions of the fruits of Trichosanthes dioica Roxb. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) and NO (nitric oxide) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.32±0.16 and 5.38±0.07 μg mL-1 for DPPH and NO assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their anti-inflammatory (carrageenan induced paw edema in rats) and antipyretic (Brewer’s yeast induced pyrexia) activities at a dose level of 100, 200 and 400 mg kg-1 body weight for MeOH extract. Methanolic extract showed a dose dependent and significant (p<0.005, p<0.05) anti-inflammatory and antipyretic effect. Dichloromethane fraction (CH2Cl2) and Ethyl acetate fractions exhibited similar activity using a dose of 200 mg kg-1 b.wt. in these models. The pharmacological activities of the (CH2Cl2) fraction were lesser than the MeOH extract and other fractions. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Altogether, these results suggest that the MeOH extract and its organic soluble fractions EtOAc could be used as a potential antioxidant, anti-inflammatory and antipyretic agent.
  Laizuman Nahar , Fatema Nasrin , Ronok Zahan and Md. Ashik Mosaddik
  Anti-nociceptive and anti-inflammatory effects of methanolic extract of Wrightia arborea (MEWA) were examined using different models in rats. MEWA was given to rats orally upto 2000 mg kg-1 b.wt. for acute toxicity study and observed for 14 days. Anti-nociceptive activity was evaluated in rats against Acetic acid induced writhing (chemically induced pain) and Tail immersion method (thermally induced pain). Acute anti-inflammatory activity of MEWA was also evaluated in Formaline-induced rat paw edema model and Carrageenan-induced hind paw edema model in rats. Results demonstrated that no mortality was found upto single dose of 2000 mg kg-1 b.wt. in rats even after 14 days observation. In comparison to control group MEWA at 100 and 200 mg kg-1 b.wt. showed highly significant anti-nociceptive activity against chemically (p<0.001) as well as thermally (p<0.05 and p<0.001) induced pain as compared to standard drugs, indomethacin and nalbufin, respectively. In the formalin test, both the doses of 100 and 200 mg kg-1 of extract significantly prevented increase in volume of paw edema (p<0.05 and p<0.01) both in the neurogenic and inflammatory phases. MEWA (200 and 400 mg kg-1 p.o.) also significantly prevented increase in volume of paw edema in Carrageenan test (p<0.05 and p<0.001). The results suggest that MEWA has significant analgesic and anti-inflammatory potential which may be mediated by central and peripheral mechanism.
  Ronok Zahan , Laizuman Nahar and Mst. Luthfun Nesa
  The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg-1) of flower of AS followed by chloroform extract (100 mg kg-1) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions.
 
 
 
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