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Articles by Roja Rahimi
Total Records ( 5 ) for Roja Rahimi
  Roja Rahimi and Mohammad Abdollahi
  The purpose of this study is to review all of these preparations and evaluate their efficacy and safety. Electronic databases were searched to obtain studies about the efficacy of locally used medications in the management of post-hemorrhoidectomy complications. Data were collected for the years 1966 to 2012 (up to September). Finally 24 relevant studies were included. The topical preparations used include botulinum toxin, Calcium Channel Blockers (CCBs), Glyceryl Trinitrate (GTN), local anesthetics, metronidazole, opioids, sucralfate and one herbal cream mainly consist of Aloe vera. Overall, topical preparations showed encouraging results in reducing pain and analgesic use and improving wound after hemorrhoidectomy. Because of better bioavailability and lower incidence of adverse events compared with other dosage forms, it is suggested to use topical preparations especially those with confirmed efficacy in the following order o GTN, CCBs, metronidazole, local anesthetics, sucralfate and botulinum toxin.
  Roja Rahimi and Mohammad Abdollahi
  Hemorrhoidal disease is a common problem which is usually not managed properly with pharmacologic interventions and will eventually require surgery. However, there are many medicinal plants that were successfully used for the treatment of hemorrhoids in the traditional and folk medicine of different countries. In this study, these medicinal plants have been reviewed and their mechanism of action and their major chemical constituents responsible for their activities have been assessed individually. Among various herbal medicines, Aesculus hippocastanum, Boswellia species, Cissus quadrangularis, Euphorbia prostrata, Juniperus species, Melastoma malabathricum, Myrtus communis and Verbascum species have got higher support from scientific evidence. These medicinal plants may exert their beneficial effects in hemorrhoids by their anti-inflammatory, analgesic and venotonic activities. Several chemical constituents were identified in these plants which may be responsible for their pharmacological activities, of which, flavonoids, terpenoids, triterpenes and tannins are the majors.
  Mohammad Hosein Farzaei , Roja Rahimi , Zahra Abbasabadi and Mohammad Abdollahi
  Many medicinal plants have been identified in Traditional Iranian Medicine (TIM) for the treatment of Peptic Ulcer (PU) but they are still unknown to scientific community. In the present study anti PU activity of these remedies were systematically reviewed and identified. For this purpose, medicinal plants proposed for the management of PU in TIM were collected from TIM sources and they were searched in modern medical databases like PubMed, Scirus, Sciencedirect and Google Scholar to find studies confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many of these plants in PU. For example, the oleogum resin of Boswellia carterii and B. serrata as a beneficial remedy for PU in TIM were demonstrated to have wound healing, cytoprotective, antisecretory, antacid, prostaglandin production and inflammatory modulating properties. Fruit and leaves of Myrtus communis was found to be antioxidant, anti H. pylori, wound healing, antisecretory, antacid and cytoprotective. The aerial part from Melissa officinalis exerts its beneficial effects in PU by antioxidant, anti H. pylori, prostaglandin elevating, cytoprotective, antisecretory, antacid and leukotriene reducing properties. Furthermore, Polygonum species demonstrated its function on PU with prostaglandin enhancement, inflammatory modulation, wound healing, cytoprotection, antacid, antioxidant and anti-H. pylori activity. In contrast, for some of herbal remedies used in TIM such as Dolichos lablab flower, Symphytum species, Zizyphus spina-christi fruit, Alisma plantago-aquatica, Cupressus sempervirens fruit, Acacia Arabica gum, Cyperus species root, Althaea officinalis flower and Nymphaea alba flower there is no enough evidence in modern medicine to prove their effectiveness in the management of PU. Pharmacological and clinical studies for evaluation of efficacy of these herbs in PU and their possible mechanisms of action are recommended.
  Roja Rahimi , Shekoufeh Nikfar and Mohammad Abdollahi
  The use of herbal medicine for the management of Inflammatory Bowel Disease (IBD) is increasing. The aim of the present study is to compare the efficacy and tolerability of herbal medicines with 5-aminosalicylates (5-ASAs) in IBD by conducting a meta-analysis. For this purpose, electronic databases were searched for studies comparing efficacy and/or tolerability of herbal medicines with 5-ASAs in different types of IBD. The search terms were: “herb” or “plant” or “herbal” and “inflammatory bowel disease”. Data were collected from 1966-2013 (up to Feb). The “clinical response”, “clinical remission”, “endoscopic response”, “endoscopic remission”, “histological response”, “histological remission”, “relapse”, “any adverse events” and “serious adverse events” were the key outcomes of interest. Eight placebo controlled clinical trials met criteria and were included. Comparison of herbal medicine with 5-ASAs yielded the following results: a significant Relative Risk (RR) of 1.28 (95% Confidence Interval (CI): 1.07-1.54, p = 0.008) for clinical remission; a significant RR of 1.19 (95% CI = 1.01-1.39, p = 0.04) for clinical response; a non-significant RR of 0.85 (95% CI: 0.34-2.12, p = 0.73) for endoscopic remission; a non-significant RR of 1.14 (95% CI: 0.99-1.3, p = 0.07) for endoscopic response; a non-significant RR of 0.8 (95% CI: 0.05-13.72) for histological remission; a non-significant RR of 1.32 (95% CI: 0.64-2.9) for histological response; a non-significant RR of 1.05 (95% CI: 0.6-1.83, p = 0.87) for relapse; a non-significant RR of 1.31 (95% CI: 0.8-2.14, p = 0.28) for any adverse events; and a non-significant RR of 1.8 (95% CI: 0.13-24.5, p = 0.66) for serious adverse events. Overall, the efficacy and tolerability of herbal medicines in IBD is comparable to 5-ASAs, but the evidence is too limited to make any confident conclusion. Further high quality, large controlled trials are still needed.
  Mohammad Hosein Farzaei , Roja Rahimi , Fatemeh Farzaei and Mohammad Abdollahi
  Diabetes mellitus is a complex metabolic disease associated with impaired insulin secretion, developing insulin resistance as well as β-cell dysfunction, that leads to abnormal glucose, protein and lipid metabolism, inflammatory responses and oxidative damages. Traditional medicines suggest a wide range of remedies for the management of symptomatologies associated with chronic disorders including diabetes mellitus. The aim of the present study is to elicit the most popular traditionally used medicinal plants for diabetes and review literatures in order to scientifically evaluate their efficacy and safety in diabetes mellitus and its complications. In addition, their molecular and cellular mechanisms of action along with active phytochemical agents were highlighted. The findings demonstrated that traditional herbal remedies perform their antidiabetic potential through different cellular and molecular mechanisms, including enhancing insulin secretion, regeneration of pancreatic β-cell, improving insulin resistance, α-glucosidase enzyme inhibitory activity and anti-inflammatory effects as well as attenuating diabetes associated oxidative stress. Suppressing hepatic glucose output and enhancing glucose uptake as key contributors in antidiabetic effect of natural remedies are mediated via stimulating glycolysis, glucose oxidation and glycogenesis, along with reducing glycogen degradation and gluconeogenesis. Since traditional natural remedies are commonly used by diabetic patients, interaction between herbs and conventional antidiabetics has also been highlighted in this study. Overall, traditional herbal remedies are possible antihyperglycemic therapeutic adjuncts and potential source of new orally active agent(s) for management of diabetes; however, more well-designed clinical trials are suggested to recognize higher levels of evidence for the confirmation of their efficacy and safety.
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