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Articles by Rita Onyekachukwu Asomadu
Total Records ( 2 ) for Rita Onyekachukwu Asomadu
  Precious Adejoh Idakwoji , Parker Elijah Joshua , Rita Onyekachukwu Asomadu , Obioma Uzoma Njoku and Okwesili Fred Chiletugo Nwodo
  Background and Objective: Tephrosia bracteolata is a medicinal plant used traditionally for the treatment of diabetes mellitus. In this study, the anti-diabetic potentials, phytochemical and proximate composition of various extracts of Tephrosia bracteolata leaves were investigated. Materials and Methods: Extraction of pulverized leaves of Tephrosia bracteolata was done using water, ethanol, chloroform/methanol (2:1). The extracts were subjected to phytochemical and proximate analyses and acute toxicity studies using standard methods. The extracts were also studied for anti-diabetic activity using alloxan (150 mg kg–1 i.p) model of diabetes. The extracts were administered to diabetic rats at dose levels of 250 and 500 mg kg–1 p.o for 28 days during which Fasting Blood Sugar (FBS), food/water intake and bodyweight were monitored as indices of anti-diabetic activity. Results: Phenols, alkaloids, saponins, glycosides and flavonoids were present in varying proportions in the extracts. Varying proportions of the proximate constituents were also observed. An acute toxicity study revealed that the extracts were non-toxic up to a dose of 5000 mg kg–1. The extracts produced significant (p<0.05) reduction in FBS, water and food intake, but no significant (p>0.05) effect on the body weight of the treated rats in comparison with the diabetic control. The ethanol extract produced a significantly (p<0.05) higher anti-diabetic effect than the other extracts. Conclusion: Ethanol extract of T. bracteolata leaves was observed to possess potent anti-diabetic effect compared to other extracts, indicating the relevance of ethanol for the extraction of the anti-diabetic principles in T. bracteolata leaves.
  Parker Elijah Joshua , Rita Onyekachukwu Asomadu , Chuma S. Eze , Ikenna Vitus Nnamani , Chizoba Ogugofor Kingsley , Chukwuemeka Paul Nweje-Anyalowu , Victor Jason Patrick and Seanpaul Amobi Obe
  Background: Cyclophosphamide is a chemotherapeutic agent, whose activation induces oxidative stress, causing nephrotoxicity. The present study ascertained the effect of the aqueous extracts of Datura stramonium seeds and leaves on cyclophosphamide-induced oxidative stress in rats. Materials and Methods: Twenty-four Wistar albino rats were divided into 6 groups of 4 rats each. All groups, except group 1, were induced with cyclophosphamide at a dose of 150 mg kg1 b.wt. Group 1 was the normal control, group 2 (positive control) was left untreated, group 3 and 4 were administered 200 and 400 mg kg1 b.wt., of the seed extract respectively, while group 5 and 6 were administered 200 and 400 mg kg1 b.wt., of the leaf extract respectively, after cyclophosphamide induction. Results: Administration of the extracts caused significant (p<0.05) decreases in catalase and glutathione peroxidase, glutathione, malondialdehyde and urea concentrations compared to group 2. The extract also led to significant (p<0.05) increases in albumin, globulin, total protein, vitamins C and E concentrations compared to group 2. However, there was no significant difference in vitamin A concentration after extract administration. Conclusion: This study showed the ability of Datura stramonium in restoring oxidative stress induced by cyclophosphamide, though not all indices considered were significantly reversed.
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