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Articles by Richard K.D. Ephraim
Total Records ( 2 ) for Richard K.D. Ephraim
  William K.B.A. Owiredu , Richard K.D. Ephraim , N. Amidu , B.A. Eghan Jnr and L. Quaye
  This study specifically evaluate the predictive performance and accuracy of the six renal function equations in patients presenting with CKD in our community. The results of these predictive equations for 50 patients using stage of CKD and/or with serum creatinine >200 μmol L-1 were compared with the recommended methods (4v-MDRD and CG). Another 55 subjects with similar age group and sex distributions but without kidney pathology were studied as control. The most accurate results were obtained with the reference equations (4v-MDRD and CG) with CG having a slight edge over 4v-MDRD equation. The sensitivity and specificity of the 4v-MDRD equation to detect Glomerular Filtration Rate (GFR) values < 60 mL/min/1.73 m2 were 67.3 and 63.9%, respectively; that of CG was 62.9 and 71.3%, respectively. These results suggest that measurement of GFR with predictive equations might be a prudent strategy for the assessment of renal function among the CKD population.
  Richard K.D. Ephraim , William K.B.A. Owiredu , Edwin F. Laing , Nafiu Amidu , Benjamin A. Eghan Jnr. and Linda Ahenkorah
  This study evaluated whether anaemia poses a cardiovascular risk and whether the risk is modified by the presence of chronic kidney disease (CKD). Anaemia was defined as haemoglobin concentration ≤11.0 for both males and females. The study population included 50 individuals with various chronic kidney diseases and/or with serum creatinine ≥200 μmol L-1. Another 55 subjects with similar age and sex distribution but without kidney pathology were studied as controls. Thirty percent of the subjects had CKD with an estimated GFR (eGFR) of <60 mL/min/1.73 m2, estimated with the modification of diet in renal disease (MDRD) equation and were more likely to be anaemic and nondiabetic, higher mean values for serum creatinine (CRT), lower values for haemoglobin (HB), haematocrit (HCT) and red blood cells (RBC). CKD subjects with anaemia had a higher prevalence of several cardiovascular (CVD) risk factors; age, male sex, diabetes and hypertension and lower haematological parameters and estimated GFR. However, they had higher total cholesterol (TC) and triglyceride (TG) level. In persons with CKD, anaemia poses a further cardiovascular risk as it increases some of the traditional cardiovascular risk factors.
 
 
 
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