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Articles by Richa Mishra
Total Records ( 1 ) for Richa Mishra
  Richa Mishra , Brijeshkunvar Mishra and N.S. Hari Narayana Moorthy
  4-phenyl-5-carboxyethyl-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones have been synthesized using the principle of Biginelli condensation from easily available starting materials. The carboethoxy group at the C5 position of the pyrimidine ring is converted to corresponding hydrazide which in turn is condensed with cyclizing agents such as aromatic aldehyde, CS2 to give fused heterocycles. The fused heterocycles are then subjected to substitution to give N3-aryl/alkylpyrimido-heterocycles in excellent yields. The compounds were tested for antimicrobial action relative to Norfloxacin against Gram positive and Gram negative bacteria using serial dilution technique.
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