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Articles by Reza Khorasani
Total Records ( 2 ) for Reza Khorasani
  Naghmeh Hajarolasvadi , Mohammad J. Zamani, , Parisa Sarkhail , Reza Khorasani , Masoomeh Mohajer , Gholamreza Amin , Abbas Shafiee , Mohammad Sharifzadeh and Mohammad Abdollahi
  The objective of the present study was to evaluate the anti-inflammatory and analgesic activities of the crude and fractioned extracts (ether, ethyl acetate, n-butanol and water) of Phlomis anisodonta (Lamiaceae) in the models of carrageenan-induced paw edema and acetic acid-induced writhing in mice. Dried powdered material from the aerial parts of Phlomis anisodonta was extracted with methanol (80%) twice. The methanol extract was separated into four fractions: after drying the methanol extract, the solid residue was dissolved in water and the water-soluble portion was successively partitioned to produce the above-mentioned fractions. The total extract, ether fraction and ethyl acetate fractions significantly reduced the number of writhings compared to the control group. Water and n-butanol fractions showed no analgesic activity. Neither the total extract nor four fractions were more effective than indomethacin in acetic acid-induced test. In carrageenan-induced inflammation test, only water and ethyl acetate fractions showed antiinflammatory activity compared to the control group. The total extract, n-butanol and ether fractions showed no antiinflammatory activity. Neither the total extract nor four fractions were more effective than indomethacin. Different types of glycosides found in the genus Phlomis could be responsible for observed effects. Variations in antiinflammatory and analgesic effects of different fractions of this plant might be attributed to the fact that different fractions of P. anisodonta contain active compounds in variable ratios and activities. A comprehensive analysis for determination and quantification of these compounds is required).
  Mona Babaie , Narguess Yasa , Azadeh Mohammadirad , Reza Khorasani and Mohammad Abdollahi
  The present study was undertaken to explore the antioxidants effects of Zataria multiflora Boiss in rats. Antioxidant activity was measured by inhibition of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, Total Antioxidant Power (TAP) and Thiobarbituric Acid Reactive Substances (TBARS) in serum of treated rats. Rats received methanolic extract of Z. multiflora by intragastric intubation at doses of 50, 100 and 200 mg kg-1 daily for 14 consecutive days. The acute toxicity test (LD50) demonstrated that Z. multiflora is not lethal up to a dose of 2000 mg kg-1 after oral administration. Treatment of rats with Z. multiflora extract showed significant antioxidant activity in the DPPH test as compared to the control. Z. multiflora at doses of 50 and 100 mg kg-1 significantly increased TAP and decreased TBARS as compared to the control. Administration of Z. multiflora at a dose of 200 mg kg-1 per day did not significantly alter serum DPPH, TAP and TBARS. Antioxidant activities of Z. multiflora at doses of 50 and 100 mg kg-1 were in all experiments comparable to that of α-tocopherol. Further studies are needed to elucidate whether Z. multiflora as herbal medicine could be useful in the management of human diseases resulting from oxidative stress.
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