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Articles by Reham Z. Hamza
Total Records ( 4 ) for Reham Z. Hamza
  Rasha A. Al-Eisa , Reham Z. Hamza , Amir E. Mehana and Nahla S. El-Shenawy
  Background and Objective: Aspartame (ASP) one of the famous artificial sweeteners used as substitution of the sugar in foods and beverages. The study was aimed to investigate the oxidative responses and histopathological changes induced by ASP on the kidney of rats and the ameliorative role of L-carnitine (LC) to prevent the toxicity. Materials and Methods: Rats were split into six groups (n = 8) as follow: control, ASP (low dose, LD) (75 mg kg–1), ASP (high dose, HD) (150 mg kg–1), 10 mg kg–1 of LC, ASP-LD+LC and ASP-HD+LC, all groups treated for successive 30 days. Results: The ASP marked decreased the renal levels of reduced glutathione (GSH), activities of antioxidant enzyme markers and increased lipid peroxidation levels. DNA damage was significantly increased in ASP-LD and ASP-HD groups as compared to control animals. The LC prevented the ASP-induced kidney damage as specified by ameliorating all the above-mentioned parameters. Histopathological changes were parallel with the biochemical alternation in ASP groups. Conclusion: The renal toxicity induced by ASP in rats could be improved by LC through different protective mechanisms.
  Fawziah A. Al-Salmi , Rasha Al-Eisa , Reham Z. Hamza , Howayda E. Khaled and Nahla S. El-Shenawy
  Background and Objective: Sodium Valproate (SV) is a medicine that is used to treat epilepsy and to prevent headache. In this study, L-cysteine (LC) was used to decrease the stress and biochemical variations induced by SV treatment. The present study investigated the defensive actions of LC vs, SV that induced testicular impairment. Materials and Methods: The rats were split into six groups (n = 10) as following: 1st control animals were saline-treated, 2nd and 3rd groups were administrated two doses of SV (100 and 500 mg kg1 b.wt.) presenting low and high doses, respectively, 4th group was treated with 100 mg kg1 of LC, in addition 5th and 6th groups were treated with SV-LD+LC and SV-HD+LC, respectively. The experiment was run for 30 successive days. Weights of the testis, serum testosterone, testicular oxidative/anti-oxidant capacity and histopathological damage scores of testis were recorded. Results: The SV group had significantly increased the tissue oxidative stress markers and significantly declined all antioxidant enzymes activities as compared to the control group. When the animals treated with combination of LC and any dose of SV, levels of oxidative parameters significantly declined, as well as the anti-oxidant significantly elevated compared to the SV-LD and SV-HD groups. The Johnsen's testicular score values showed improvement when LC was co-treated with the SV. Conclusion: Current results indicated that LC had partial protective effects against SV-induced testis damage at the biochemical and histopathological levels that could be due to the enhanced tissue anti-oxidant capacity.
  Reham Z. Hamza , Fawziah A. Al-Salmi and Nahla S. El-Shenawy
  Background and Objective: The potential benefit of green synthesis zinc oxide nanoparticles (ZnO NPs) is still a deprecatory issue. The aim of the present research was to elucidate the anti-hyperlipidemia of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate (MSG). Materials and Methods: Eight different groups of male rats were used: Group I was the control, group II received GTE (1 mg mL–1), group III was treated with ZnO NPs (10 mg kg–1), groups IV and V received MSG in two different doses (6.0 and 17.5 mg kg–1), group VI treated with ZnO NPs/GTE complex, groups VII and VIII were given ZnO NPs/GTE complex plus MSG in different doses. The effect of ZnO NPs/GTE complex against MSG toxicity through studying the alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation have been described. The rats that were given MSG only had a highly significant elevation in liver enzymes and severe lipid metabolism changes. Results: The findings for group VII and VIII clarify the efficacy of ZnO NPs/GTE complex as a hepato-protectant on MSG alone through improving the liver enzyme activity along with the lipid profile. The activities of ALT, AST, LDH, ALP and γ-GT in the serum were significantly reduced. Conclusion: ZnO NPs/GTE complex was proved to be a potential hepatoprotective as it significantly ameliorates the hepatotoxicity induced by MSG through hyperlipidemia reducing effect.
  Sayed A. Abd El-Aziz , Ahmed A. Said , Mohamed H. Khairy , Shahira H. Mahmoud , Walaa A. Habib and Reham Z. Hamza
  Background and Objective: Copper is a trace element vital to life, but the toxic effect of water pollution with it on fish is now exhibited which is known to affect vital organ especially liver, kidney and gills. This investigation was intended to test the possible protective role of garlic extract against the toxicity of copper sulfate to Clarias gariepinus. Materials and Methods: In this study, 120 apparently healthy African catfish (Clarias gariepinus) of average weight (150±5 g) were selected as test organism. Fish were divided into four equal groups each of 30 fish. Results: The levels of some liver and kidney function parameters (ALT, AST, ALP, urea and creatinine) were significantly increased with significant lowering in total protein, albumin, total globulins and its fractions (%) (α1, α2, β, γ-globulin) as well as severe histopathological changes in copper sulfate treated group compared with control group. Interestingly the supplementation of sulphur containing antioxidants (garlic extract) has appeared to minimize the effects of copper at all-time intervals by significant increase in the serum level of total protein, albumin, globulins and modulating the deranged liver and kidney function parameters minimizing histopathological alterations. Conclusion: The main finding of this study was that CuSO4 may cause some alternations in the biochemical parameters and histopathological findings of the studied fish even in therapeutic dose. It seems that simultaneous exposure of fish to garlic extract was found to counteract the toxic effects of copper sulfate indicating their potential therapeutic activity against copper toxicity in fish.
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