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Articles by Reham Z. Hamza
Total Records ( 3 ) for Reham Z. Hamza
  Nahla S. El- Shenawy , Reham Z. Hamza , Hayat A.A. Ismail and Howayda E. Khaled
  Background and Objective: Dimethylnitrosamine (DMN) is a representative chemical of a family of N-nitroso compounds and has been found in processed meats and industrial products. Alpha Lipoic Acid (ALA) found naturally in plants and animals is involved in many different antioxidant functions in all body tissues. So, the study was designed to find out the efficacy of ALA in reducing the DMN-toxicity in male mice by measuring some biomarkers functions of liver as well as oxidative stress parameters and histopathological changes. Materials and Methods: Animals were divided into 6 groups (n = 8) and received their treatment for 4 weeks as follows: Groups 1-4 served as control, ALA-treatment (16.12 mg kg–1), DMN-low dose treatment and DMN-high dose treatment, respectively. Groups 5 and 6 were received ALA before DMN-low and DMN-high dose, respectively. Results: The treatment of the mice with DMN caused significant changes in serum biomarker enzymes of liver, lipid profile, protein content and myeloperoxidase as well as hepatocytes lipid peroxidation, superoxide dismutase, catalase, glutathione peroxidase, nitric oxide, xanthine oxidase and total antioxidant capacity. Histopathological analysis of liver confirmed the oxidative stress results. Conclusion: Concomitant administration of ALA with DMN significantly protected most of the changes induced by DMN suggesting its protective efficacy.
  Mohammad S. Al-Harbi and Reham Z. Hamza
  Background and Objective: Diabetes mellitus is a persistent syndrome affecting carbohydrate, fat and protein metabolism. The current study was undertaken to assess and evaluate the ameliorator property of selenium and chromium each alone or in combination as antioxidants and as a biological membrane stabilizer in the caring against diabetes mellitus oxidative stress. Methodology: The rats were divided into seven groups (10 per group). The 1st group was served as a control group, while, the 2nd group was treated with STZ and considered as (Diabetic untreated group). The 3rd and 4th groups were normal and treated with Se or Cr each alone. The last three groups were diabetic and treated with either Se and/or Cr each alone or in combination and all animals were treated for 30 days. Results: Administration of STZ (50 mg kg–1 i.p.) to rats resulted in hyperlipidemia, an increase in renal parameters as well as the pancreatic and hepatic MDA level and decreasing glutathione (GSH and CAT) contents of the liver and pancreas. While, inducing an increment in (TNF-α and CRP) as compared to control group. In contrast, the administration of Se (0.5 mg kg–1) or/and Cr (600 Fg day–1) to diabetic rats attenuates the toxicity of diabetes, objectified by pancreatic tissues improvement as in TEM sections. But, this alleviation is more pronounced in the diabetic group treated with the both antioxidants. Thus, the synergistic effect of Se and Cr is most powerful in reducing the toxicity induced by STZ and improving the liver and the pancreas antioxidant status. Conclusion: Diabetes, induced harmful variations in metabolism by elevation of oxidative stress markers and thus Se and Cr are struggling against the oxidative stress via their elaboration in metabolism in addition to their antioxidant properties which may reduce the suffering of diabetic patients.
  Reham Z. Hamza , Shaden E. Al-Motaan and Nusrat Malik
  Background and Objectives: Selenium (SeNPs) and vitamin C have a lot of significant protective antioxidant effects. Acrylamide (ACR) is found in starchy foods and breads that has been heated over long periods over 120°C. The current study aimed to evaluate the ameliorative roles of SeNPs and/or vitamin C on acrylamide (ACR)-induced hepatotoxicity in male mice. Materials and Methods: Total 42 male mice were divided randomly to seven groups: Control, ACR, SeNPs, vitamin C, ACR plus SeNPs, ACR plus vitamin C, ACR plus SeNPs and vitamin C. Hepatic enzymes levels (Alanine and aspartate aminotransferases) and tumor necrosis factor-alpha as well as the antioxidant markers: Superoxide dismutase, glutathione-S-transferase, catalase and glutathione reductase were evaluated. Histological, transmission electron microscopic and comet assay alterations in the hepatic cells as markers of hepatic damage after the ACR administration alone or combined with SeNPs and/or vitamin C were done. The ACR genotoxic effects were also assessed and the ameliorative roles of SeNPs and/or vitamin C on the liver cells were recorded as well. Results: Results clarified that vitamin C and SeNPs administration declined ACR-elicited increment in aminotransferase levels and declined oxidative stress significantly. Additionally, vitamin C combined with SeNPs had a potent synergistic effects and increased the antioxidant enzymes significantly and declined lipid peroxidation markers as compared with ACR-group. Conclusion: It is apparent that both vitamin C and SeNPs prohibit the liver damage and enhance the redox state in male mice.
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