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Articles by Ravindra Semwal
Total Records ( 2 ) for Ravindra Semwal
  Ravindra Semwal , Deepak Kumar Semwal , Ruchi Badoni , Swati Gupta and Anil Kumar Madan
  Encouraged by rapid and promising progress in cancer nanotechnology, researchers continue to develop novel and efficacious nanoparticles for drug delivery. The interest in self-assembling polymeric nanoparticles as drug delivery vehicles is growing now a day, in which polymers can lead to supramolecular systems and is related to their functions as carrier for targeting the various cytotoxic drugs. This review article gives the idea of selection, preparation, morphology, stability and drug release characteristics of self-assembled polymeric systems. The release characteristic of drugs from these polymeric systems is dependent on the drug loading contents and chain length of the hydrophobic/hydrophilic part of the copolymers. The review also focuses the recent advances in self-assembled polymeric system.
  Deepak K. Semwal , Ruchi B. Semwal and Ravindra Semwal
  Stephania glabra (Roxb.) Miers (Menispermaceae) is a large, climbing shrub, indigenous to lower Himalaya of India. This plant has long been used for the treatment of asthma, tuberculosis, dysentery, hyperglycemia, cancer, fever, intestinal complaints, sleep disturbances and inflammation in India. The study aim is to isolate the chemical constituents from the plant tubers and to evaluate antimicrobial activity of isolated constituents. Ethanolic extract from tubers was subjected to column chromatography using silica gel as adsorbent for isolation of chemical constituents. The agar diffusion method was adopted for antimicrobial activity to determine IZD and MICs. A tetrahydroberberine alkaloid named 8-(4’-methoxybenzyl)-xylopinine has been isolated from the column eluent of CHCl3:MeOH (1:9). The compound showed antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Eschericha coli and Salmonela typhi with IZD range of 8-19 mm at MIC of 25-100 μg mL-1. Erythromycin (10 μg mL-1) was used as standard antibiotic. Present study concludes that 8-(4’-methoxybenzyl)-xylopinine have significant antibacterial activity.
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