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Articles by Ravichandran Ramanibai
Total Records ( 2 ) for Ravichandran Ramanibai
  Kameswaran Ravichandran and Ravichandran Ramanibai
  The chemopreventive effect of the flavanoidal fraction of Indigofera tinctoria were evaluated in Swiss albino mice using 16 week medium term model of benzo (a) pyrene (BP)-induced lung tumor. Lung tumor was induced biweekly through oral incubation of BP for 4 weeks. The oral administration of flavanoidal fraction of I. tinctoria (100 mg kg-1 body weight) showed a significant increase in antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT) and non enzymic antioxidants like reduced glutathione (GSH), vitamin C and vitamin E were significantly increased when compared to BP treated groups. The effect is much more pronounced in pretreatment regime than in the post treatment regime. The levels of lung marker enzymes were significantly decreased in both the treatment regimes when compared to cancer induced group. The levels of lipid peroxidation were significantly decreased in the flavanoidal fraction of I. tinctoria treated regimes. The elevated levels of glycoproteins were normalized in the animals subjected to flavanoidal fraction of I. tinctoria treatment. The histopathological studies confirmed the protective effect of the extract by showing the reappearance of alveolar spaces in the treatment regimes, where the effect is pronounced much in the pre treatment regime than the post treatment regime. From the results obtained it is concluded that flavanoidal fraction of I. tinctoria had protective effects on BP induced lung cancer.
  Thiruvanmiyoor Ravichandran Kameswaran and Ravichandran Ramanibai
  The aerial parts of the plant was investigated for its antiproliferative activity in human Non Small Cell Lung Cancer cells A-549. The results showed that the flavanoidal fraction of methanolic extract of the aerial parts of the plant inhibited the proliferation of A-549 cells as measured by MTT assay. Flow cytometric analysis showed that flavanoidal fraction of methanolic extract of I. tinctoria blocked cell cycle progression in G0/G1 phase. In addition flavanoidal fraction of methanolic extract of I. tinctoria induced A-549 cell apoptosis as determined by propidium iodide staining. We suggests that flavanoidal fraction of methanolic extract of I. tinctoria activity might be potentially contribute to its overall chemo preventive effect against lung cancer and can possibly be considered for future therapeutic application.
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