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Articles by Rathinavelusamy Paramaguru
Total Records ( 1 ) for Rathinavelusamy Paramaguru
  Papiya Mitra Mazumder , Rathinavelusamy Paramaguru , Anuradha Mohanty and Dinakar Sasmal
  Background: Barleria lupulina is well recognized traditional medicine in the treatment of diabetes mellitus but no scientific data has been reported to its ethnomedical use in eye related long term complications of diabetes. Objective of the present study is to evaluate the anti-cataract activity of leaves of Barleria lupulina Lindl. along with its aldose reductase potential. Materials and Methods: Methanol extract of Barleria lupulina Lindl. (MEBL) was successively fractionate with hexane (HFBL), ethyl acetate (EFBL) and the aqueous fraction (AFBL). All the fractions and methanol extract were subjected to qualitative and quantitative phytochemical screening. In vitro antioxidant activity of the same was assessed by free radical scavenging activity using DPPH and hydrogen peroxide assay. The active ethylacetate fraction (EFBL) was further subjected to in vitro anti cataract evaluation against glucose induced cataractogenesis by using goat lenses. Results: The lenses incubated with EFBL at 200 and 400 μg mL-1 concentration seemed to retard the progression of lens opacification and showed a significant restoration of glutathione, SOD level (p<0.01) and reduced the level of TBARS (p<0.01) when compared with positive control group (glucose 55 mM). EFBL showed promising percentage inhibition of aldose reductase activity with lower IC50 value (50.118 μg mL-1). Conclusion: Hence, this study demonstrated that the EFBL possess significant anticataract, antioxidant and aldose reductase inhibition properties.
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