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Articles by Rana M. Ashraf
Total Records ( 1 ) for Rana M. Ashraf
  Ehab M.M. Ali , Wafaa Ibrahim , Rana M. Ashraf and Ehab Tousson
  Background: Thyroid hormone has profound effects on the cardiovascular system and a regulatory effect on the rate of heme oxidation in the liver. Inducible isoform of heme oxygenase (HO-1) protects the heart and vasculature in pathological conditions. The present study aimed to identify the role of heme oxygenase in cardiac changes in thyroidectomized rats. Materials and Methods: Sixty male Wistar rats were equally divided into seven groups; the first and second groups were the control and sham operated groups, respectively while the 3rd and 4th groups were subjected to sham operation then treated with hemin (G3) and KTZ (G4). The 5th group (G5) was thyroidectomized group. The 6th and 7th groups were subjected to thyroidectomy then treated with hemin (G5) and KTZ (G6), respectively. Results: Hypothyroidism is documented by significant decrease in T3 accompanied with significant increase in serum TSH levels in thyroidectomized rats. The results obtained revealed that oxidative stress due to hypothyroidism has a detriment effect on cardiac tissue by depending on the result of cardiac Protein Carbonyl Content (PCC) as a marker of tissue damage and a negative significant correlation between cardiac PCC and serum Ferric Reducing Antioxidant Power (FRAP) as marker of Total Antioxidant Capacity (TAC). The Inducible Nitric Oxide Synthase (iNOS) activity in cardiac tissue showed significant decrease in thyroidectomized rats and its value was increased significantly upon treatment with hemin or ketoconazole (KTZ) as compared with sham operated rats. Treatment of thyroidectomized rats with hemin improves the intensity of iNOS immunoreactive cells demonstrating the recovery of some injury. Conclusion: There is a positive significant correlation between hepatic HO and iNOS in cardiac tissue. The paradoxical effect of both inducer and inhibitor of HO-1 on iNOS needs further studies. Also, to address this inquiry we need further investigation on time and dose-dependent effect of both inducer and inhibitor on cardiac tissue.
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