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Articles by Rami S. AlAzab
Total Records ( 2 ) for Rami S. AlAzab
  Nizar M. Mhaidat , Ahmed S. Abu-zaiton , Karem H. Alzoubi , Wael Alzoubi and Rami S. Alazab
  The present study aimed to evaluate the antihyperglycemic effects of Foeniculum vulgare extract in streptozotocin (STZ)-induced diabetes in rats. Diabetes was induced via an intraperitoneal injection of STZ (50 mg kg‾1 b.wt.). Control and diabetic animals were treated by F. vulgare extract (100 mg kg‾1) or a similar volume of vehicle. Animals body weight and water intake were monitored and recorded. Blood glucose, amylase, total cholesterol alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine were determined using standard biochemical methods. Results indicated that treatment of diabetic animals with F. vulgare extract restored body weight to be similar to control animals. Additionally, treatment with F. vulgare reduced hyperglycemia in diabetic animals, yet it did not affect glucose levels in control animals. Similarly, treatment of diabetic animals with F. vulgare significantly reduced the diabetes-associated elevation in levels of amylase, total cholesterol, ALT, AST, urea and creatinine suggesting a protective effect on the cardiovascular system, the liver and kidneys. These findings demonstrated the effectiveness of F. vulgare extract in management of STZ-induced diabetes and some of its related complications in animal models. Thus, a more comprehensive characterization of the medicinal potential of F. vulgare will provide understanding of its mechanisms of action and its possible use for diabetes.
  Rola S. Saqan , Ameer K. Alaraji , Rami S. AlAzab and Wasim Khasawneh
  Botulinum toxin-A has been used in the treatment of overactive bladder effectively. The objective of this study was to investigate the effects of using Botulinum Toxin-A (BoNT-A) in reducing the frequency of urinary tract infections. The 119 patients were included in this study. A retrospective design was conducted to collect data from patients who visited urology clinics at King Abdulla University Hospital. Results showed that the mean age of study participants was 25.80+22.63 years, among them were 35(29.4%) males, 68.1% of participants had at least one positive urine culture in the 6 months preceding the treatment. Among positive cultures, E. coli was the most prevalent organism (42.6%) and the rate of mixed growth was about 30%. Post-treatment urine cultures showed that about 44.5% were positive of which E. coli was the most prevalent (37%). The rate of mixed growth had increased to about 39.22%. Taken together, our study showed that using botulinum toxin-A is helpful in reducing urinary tract infection. Furthermore, botulinum toxin-A increased the frequency of mixed growth and we might speculate that using a prophylactic antibiotic course accompanied with its use is recommended.
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