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Articles by Ramachandran Venugopal
Total Records ( 5 ) for Ramachandran Venugopal
  Peramaiyan Rajendran , Ramachandran Venugopal , Ganapathy Ekambaram , Arumugam Aadithya and Dhanapal Sakthisekaran
  Cancer chemoprevention involves prevention, delay, or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. A large number of potential chemopreventive agents are known, some of which have proven effective in clinical trials. These agents may function by a variety of mechanisms, directed at all major stages of carcinogenesis. One mechanism of particular note involves the inhibition of biosynthesis; of polyamines such as spermine, spermidine and putrescine are promising drug for chemoprevention. In the present study we evaluate chemopreventive efficacy of mangiferin against Benzo(a)Pyrene (B(a)P) induced lung carcinogenesis. Male Swiss albino mice strains were selected for the present investigation. Lung carcinoma was induced with B(a) P (50 mg kg-1 body weight, orally) and the treatment was started by the oral administration of mangiferin (100 mg kg-1 body weight). The modulatory effect of the mangiferin was examined on lung and liver to evaluate the level of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation. Mangiferin significantly decreased the levels of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation that were found to be increased in lung cancer bearing animals. Mangiferin could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation.
  Ramachandran Venugopal , Palaniyandi Senthilnathan , Venkatraman Magesh , Balasubramanian Rajkapoor and Dhanapal Sakthisekaran
  The present study was conducted to ascertain the chemotherapeutic efficacy of Solanum trilobatum when administered along with paclitaxel against experimental lung carcinogenesis. Healthy male Swiss albino mice (6-8 weeks old) were treated with Benzo (a) pyrene (50 mg kg-1 body weight) to induce lung cancer. Paclitaxel at a dose of 33 mg kg-1 body weight intraperitoneally and Solanum trilobatum 200 mg kg-1 body weight orally was administrated for four weeks to lung cancer bearing animals. The level of lipid peroxides (LPO) was found to be markedly increased in carcinogen-administered animals, in contrast the activities/levels of the antioxidant status both in lung and liver were decreased in carcinogen administered animals. Upon Solanum trilobatum along with Paclitaxel administration the above pathological changes were bring back to near normal. From these findings we have concluded that Solanum trilobatum when administered along with paclitaxel prevents LPO and protects antioxidant system strongly aganist Benzo(a)pyrene induced lung cancer.
  Venkatraman Magesh , Ramachandran Venugopal , Konga Durga Bhavani and Dhanapal Sakthisekaran
  In recent years, considerable emphasis has been focused on identifying new cancer chemopreventive agents, which could be useful for the human population. The present study was aimed to investigate effect of crocetin on Xenobiotic enzymes and glutathione metabolizing enzymes in Benzo(a)pyrene (B(a)p) induced lung cancer in Swiss albino mice. The lung cancer bearing mice shows elevated level of Phase I enzymes (cytochrome P450, cytochrome b5 and NADPH cyto.C reductase), glutathione-metabolizing enzymes (glutathione peroxidase, glutathione reductase and glucose-6-phosphoate dehydrogenase) and decreased level of Phase II enzymes (UDP-glucuronyl transferase, glutathione S-transferase, quinone reductase). Oral administration of crocetin (50 mg kg-1 body weight) to B(a)p administered animals altered the enzymes level near to normal during initiation and post-initiation treatment. Based on the results, our finding suggests that crocetin have protective role against B(a)P induced lung carcinogenesis.
  Ramachandran Venugopal , Dhanapal Sakthisekaran , Balasubramanian Rajkapoor and Ikuo Nishigaki
  The aim of the present study was to evaluate the protective effect of mangiferin on Human Umbilical Vein Endothelial Cells (HUVEC) against glycated protein-iron chelate induced toxicity. HUVEC incubated in glycated protein either alone or combined with iron chelate showed a significant (p< 0.001) elevation of Lipid Peroxidation (LPO) accompanied by depletion of Superoxide Dismutase (SOD), catalase, Glutathione Peroxidase (GPx) and Glutathione Reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased glutathione S-Transferase (GST). Treatment of HUVEC with mangiferin at a concentration of 5 and 10 μg significantly decreased the level of LPO and altered antioxidants, cytochrome c reductase and GST levels to near normal in a dose dependent manner. Present results suggest that mangiferin have protective effect against glycated protein-iron chelate induced toxicity.
  Ikuo Nishigaki , Balasubramanian Rajkapoor , Peramaiyan Rajendran , Ramachandran Venugopal , Ganapathy Ekambaram , Dhanapal Sakthisekaran and Yutaka Nishigaki
  Consumption of fruits and vegetables has been associated with a low incidence of cardiovascular and other chronic diseases. The present study was aimed at evaluating the protective effects of fresh apple extract (AE) on human umbilical vein endothelial cells (HUVEC) exposed to cytotoxic glycated protein (GFBS)/iron (FeCl3) chelate. The experimental design comprised 10 groups with 5 flasks in each group. Group I was treated with 15% foetal bovine serum (FBS). Groups II, III and IV were treated with GFBS (70 µM), FBS + FeCl3 (20 µM), and GFBS + FeCl3, respectively. The other six groups were as follows: Group V, GFBS + AE (100 µg); Group VI, FBS + FeCl3 + AE (100 µg); Group VII, GFBS + FeCl3 + AE (100 µg); Group VIII, GFBS + AE (250 µg); Group IX, FBS + FeCl3 + AE (250 µg); and Group X, GFBS + FeCl3 + AE (250 µg). After 24 h incubation, cells were collected from all the experimental groups and assessed for lipid peroxidation (LPO) and activities of the antioxidant enzymes cytochrome c reductase and glutathione S-transferase (GST). HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p < 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities. Treatment of GFBS- or GFBS + FeCl3-exposed HUVEC with AE at 100 or 250 µg significantly decreased the level of LPO and returned the levels of antioxidants cytochrome c reductase and GST to near normal in a dose-dependent manner. The extracts recovered viability of HUVEC damaged by GFBS-iron treatment in a concentration-dependent manner. These findings suggest a protective effect of AE on HUVEC against glycated protein/iron chelate-induced toxicity, which suggests that AE could exert a beneficial effect by preventing diabetic angiopathies.
 
 
 
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