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Articles by Ram Rammohan
Total Records ( 2 ) for Ram Rammohan
  B. Venkatrajah , V. Vanitha Malathy , B. Elayarajah , Mohan , R. Rajendran and Ram Rammohan
  Wound healing is a complicated process with haemostasis, neovascularisation and re-epithelisation. To accelerate the process, moisture, sterile condition without microbial intervention and plant metabolites to influence the wound healing related metabolic functions are needed. The 40s Ne yarn was used to prepare the wound dressing cotton gauze. The physical properties such as areal density, air permeability and stiffness of gauze were analysed. Mixed polymer formulations like chitosan-sodium alginate, sodium alginate-calcium alginate and chitosan-sodium alginate-calcium alginate were prepared and coated separately on cotton gauze surface using pad-dry-cure method. The herbal extract of Bletilla striata was immobilized on the polymer coated fabrics to increase the rate of wound healing. The qualitative and quantitative antibacterial assays of coated cotton gauze was evaluated against the bacteria S. aureus ATCC 6538 and E. coli ATCC 10229 using the standard EN ISO 20654:2004 and AATCC testing methods. Animal model was used to reveal the wound closure effect of the prepared specimens. A novel design of various polymer coated cotton gauze fabric for wound healing with antimicrobial activity was developed using 40s Ne yarn. The cotton gauze with all the three polymers and herbal extract showed rapid wound healing effect due to excellent antibacterial activity by chitosan, moisture retaining by alginate and cell proliferation and tissue regeneration effect from B. striata extract in albino rat animal models.
  B. Venkatrajah , V. Vanitha Malathy , B. Elayarajah , R. Rajendran and Ram Rammohan
  Wound healing is a long and complex process. To improve wound healing, the wound dressing cotton gauze can be functionalized by imparting moisture holding and antibacterial ability. Moisture is an important factor for wound healing and the absence of microbial intervention can accelerate wound healing process. Direct alkylation method was used to synthesis carboxymethylated chitosan with water solubility, biocompatibility and antibacterial activity. Calcium alginate was used along with modified chitosan as moisture gaining polymeric agent. Pad-dry-cure method was employed to coat both the polymers on cotton gauze surface, which was weaved using 40s Ne cotton yarn. After coating, the cotton was analysed for its polymer add-on percentage, antibacterial action against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10229. The persistence analysis of antibacterial activity ensures the polymer withstanding ability on cotton gauze surface. SEM detection of polymers with cotton threads confirms their presence. Wound healing action of the polymer coated cotton gauze was determined using albino rats as animal model.
 
 
 
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