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Articles by Rakhshanda Nawaz
Total Records ( 3 ) for Rakhshanda Nawaz
  Suriya Bibi , Rakhshanda Nawaz , M. Nawaz , Muhammad Shahid and Sobia Qamar Kiani
  The biokinetics parameters were investigated following oral dose of 1g secnidazole in healthy female volunteers. The plasma samples were deproteinized by ZnSO4 and NaOH analyzed by HPLC. The mean maximum concentration in plasma was found to be 23.08?0.8 after 2.5 h of drug administration. The area under curve (AUC) was 349.05 ± 20.9 h mg L-1. The clearance and volume of distribution were 0.44 ± 0.37 L h-1 and 11.09 ± 7.81 L respectively. The elimination half life was 13.86?0.92 h. The values for absorption rate constant and absorption half life were 2.97 ± 0.46 L h-1 and 0.27?0.03 h. The maximum concentration 16.24 ± 0.48 mg L-1 was achieved in 1.77 ± 0.16 h. These parameters showed that protein deproteinization method and analysis techniques are valid for the protein analysis of secnidazole.
  Fouzia Zahid , Rakhshanda Nawaz , Zahid Mahmood , Muhammad Shahid and Khurram Shahzad
  The present study was conducted for urinary excretion of aspirin in adult female volunteers. Aspirin (2x300 mg) was given to each volunteer orally and urine samples were collected at different time intervals and analyzed by spectrophotometric and thin layer chromatographic methods. The results indicated that the free aspirin excreted as salicylic acid at 720 min was 0.142 ± 0.073, 0.029 ± 0.015 and conjugated drug was 0.066 ± 0.022 mg, respectively. The value of dose excreted as total salicylic acid in the urine was 0.594 ± 0.108%. These values deviate from the literature values emphasizing that such kind of studies must be conducted in local populations so that an appropriate dosage can prescribed.
  Ambreen Ijaz , Haq Nawaz Bhatti , Saba Rasheed , Bazghah Sadaf and Rakhshanda Nawaz
  The pharmacokinetics of acetylsalicylic acid, a non-steroidal anti-inflammatory agents, was studied in twelve healthy young females after oral administration of 600 mg aspirin. Blood samples were collected at pre-determined time intervals. The concentration of aspirin as free salicylic acid was analyzed colorimetrially at 530 nm and mean ±SE value in blood was found to be 30.33±0.63 μg mL–1. Individual pharmacokinetic parameters were estimated by using two compartment open model. Mean±SE values were found to be Cmax 44.54±0.46 mg L–1, tmax 1.87±0.05h, t1/2α 1.17±0.25 h, Ka 0.85±1.12 h–1, AUC 275±2.73 L–1, Vd 10.90±0.76 L, t1/2β 4.69±0.55 h and TBC 1.68±0.06 L h–1. ASA values established in this study were in agreement with those reported by other authors.
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