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Articles by Raju Senthil Kumar
Total Records ( 2 ) for Raju Senthil Kumar
  Raju Senthil Kumar , Balasundaram Jayakar and Balasubramanian Rajkapoor
  The antitumour activity of ethanol extract of Indigofera trita L.f (EIT) was evaluated against Ehrlich Ascites Carcinoma (EAC) tumour model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumour volume. Oral administration of EIT (200 and 400 mg kg-1) increased the survival time and decreased the average body weight of the tumour bearing mice. After 14 days of inoculation, EIT was able to reverse the changes in the hematological parameters, protein and PCV consequent to tumour inoculation. Oral administration of EIT was effective in reducing solid tumour mass development induced by EAC cells. The results indicate that EIT possess significant antitumour activity on dose dependent manner.
  Raju Senthil Kumar , Rangasamy Manivannan , Ayyasamy Balasubramaniam and Balasubramanian Rajkapoor
  The ethanol extract of Indigofera trita (EIT) was studied for its antioxidant and hepatoprotective properties. The ethanol extract exhibited potent in vitro antioxidant activity as evidenced by the low IC50 values in the scavenging of ABTS, DPPH and hydroxyl radical methods. The IC50 values obtained were 9.50 ± 0.50 and 19.91 ± 1.73 μg mL-1, respectively for ABTS and DPPH methods. The IC50 values obtained for hydroxyl radical scavenging by p-NDA and deoxyribose methods were found to be 104.50 ± 4.50 and 99.00 ± 0.28 μg mL-1, respectively. The treatment with the EIT at 200 and 400 mg kg-1 body weight showed a significant and dose dependent decrease in the levels of SGOT, SGPT, ALP and TBARS and significant increase in the levels of albumin, total protein, SOD and catalase, when compared to CCl4 treated rats. The treatment with EIT exhibited better results than the standard vitamin-E treatment in some of these parameters. Thus, the EIT showed significant antioxidant and hepatoprotective activity. These results were also confirmed by the histological observation.
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