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Articles by Rajesh Kumar
Total Records ( 10 ) for Rajesh Kumar
  Rajesh Kumar , A.K. Verma , Amit Kumar , Mukesh Srivastava and H.P. Lal
  With the increasing trends of pet ownership the chances of campylobacteriosis are also increasing as these pets are kept in close visicinity of owners. The prevalence and antimicrobial sensitivity profiles of Campylobacter isolates from faeces of dogs attended in veterinary practice at Teaching Veterinary Clinical Complex, Mathura, India. During the period of investigation (October 2009 to April 2010), 100 rectal swabs from dogs were collected and transported to the laboratory for further investigations. Bacteriological examination revealed 51.00% prevalence rate of Campylobacter isolates in dogs faecal samples. The disc-diffusion method was used to know the susceptibility of all the 51 Campylobacter isolates against 10 commonly used antimicrobials in pet animal practice. High rates of resistance were observed to erythromycin (90.20%), tetracycline (88.23%), ampi-cloxacillin (88.23%), ciprofloxacin (80.39%), enrofloxacin (68.63%) and aymoxycillin-clavulanic acid (19.61%). All the Campylobacter isolates were susceptible to amikacin, levofloxacin and streptomycin. Erythromycin and ciprofloxacin are drugs for treatment of human campylobacteriosis. The high resistance rate to these drugs among Campylobacter isolates from dog faeces is of public health significance as dogs are supposed to be the main source of infection in human beings.
  Rajesh Kumar , A.K. Verma , Amit Kumar , Mukesh Srivastava and H.P. Lal
  Campylobacteriosis is one of the leading causes of gastroenteritis in humans and various researches suggested that owning a pet is a risk factor for the disease. To determine the prevalence and risk indicators for Campylobacter sp. infecting dogs attending veterinary practice at TVCC, DUVASU, Mathura, 100 dogs with and without the clinical symptoms of diarrhoea were examined and the prevalence of Campylobacter sp. was 51.0%. Breed wise prevalence showed that nondescript (73.68%) dogs were more likely to carry Campylobacter sp. A significant difference in isolation rates was observed between younger and older dogs: 56.58% of the younger dogs (≤ 1 year) were positive, compared with 33.33% of adult dogs (> 1 year) (p<0.01) as seen at the veterinary University, Mathura, India. Dogs sharing a household with another dog, dogs that had not received antibiotic treatment in the previous months and the age of the dog were significant indicators of Campylobacter carriage. Recent diarrhoea or vomiting in dogs with Campylobacter, breed, sex or vaccination status were not statistically significant. The high prevalence of Campylobacter in puppies supports the hypothesis that dogs, particularly young ones shed Campylobacter spp., which can be of impact for public health.
  P. Pandey , Rajesh Kumar , V.R. Pandey , K.K. Jaiswal and M. Tripathi
  Heterosis is the most important phenomenon for breaking the yield barrier level of crops. Hence, an experiment was undertaken to identify the best heterotic combinations for exploitation of heterosis or hybrid vigour. In this context, three cytoplasmic male sterile lines were crossed with twenty genotypes of pigeonpea in a linextester mating design during Kharif 2011-12. Thus, the resultant 60 hybrids along with their parents and standard check variety (NDA 2) were evaluated in a randomized block design with three replications during Kharif 2012-13. The results indicated that the manifestation of heterobeltiosis for seed yield per plant was significantly superior of fourteen hybrids ranging from -85.06-33.74% and fifteen hybrids over standard variety ranging from -82.57-26.28%. Most of the crosses which exhibited superiority over better parent or standard variety for seed yield also showed significant heterosis for primary branches per plant, secondary branches per plant, pods per plant, seeds per pod, biological yield per plant and harvest index. Besides seed yield, substantial heterosis was also observed in negative as well as positive direction for remaining characters but number of crosses showing significant estimates of heterosis and its degree varied from one character to another. The best cross combinations in order of merit seed yield and other yield components were NDACMS 1-6AxNDA 98-6, NDACMS 1-6AxNDA 5-14, NDACMS 1-4AxIPA 208, NDACMS 1-6AxICP 870, NDACMS 1-6AxNDA 96-1, NDACMS 1-6AxNDA 8-6, NDACMS 1-6AxICP 2309 and NDACMS 1-4AxBahar. Commencing the experimental findings it could be accomplished that the crosses, NDACMS 1-6AxNDA 98-6, NDACMS 1-6AxNDA 5-14, NDACMS 1-4AxIPA 208, NDACMS 1-6AxICP 870 were found to be more than 20% standard heterosis for seed yield recommended for commercial utilization.
  Narinder Pal Singh , Rajesh Kumar , Deo Nandan Prasad , Sarita Sharma and Om Silakari
  The aim of present study was to carry out the synthesis of benzotriazole substituted acridine derivatives and to evaluate their antibacterial activity. The 9-chloroacridine derivatives 1a-b was treated with o-phenylenediamine in presence of methanol to obtain 9-substituted acridine derivatives 2a-b. These were finally cyclized to get benzotriazole substituted acridine derivatives 3a-b. The synthesized compounds were then established on the basis of IR and 1H NMR spectra data and screened for antibacterial activity. Successfully synthesized four acridine derivatives. Out of these, two compounds 2a and 2b showed moderate activity while two compounds 3a and 3b showed good antibacterial activity. The derivatives with free amine group 2a-b were less prone towards antibacterial activity as compared to derivatives lacking the free amine group 3a-b.
  Smita jhajharia , Seema Verma and Rajesh Kumar
  Cancer has become one of the most significant reasons for causing high rates of mortality over the globe. Mortality rate due to cancer in India is also very high. It is also considered as the second most common disease to be responsible for highest mortality rate every year in the country. Among the different types of cancers, breast cancer is the leading problem in India. The diagnosis of breast cancer and its subsequent treatment has a significant impact on the health and well being of women. Therefore, the women have to face substantial barriers towards the quality of life they deserve post-treatment as well. In the recent years, measurement of the quality of life (QOL) of the breast cancer patients in India has gained attention of the clinical research fraternity. Assessment of QOL is also important for understanding the consequences of the treatment. Various factors have been found to influence QOL in the breast cancer patients. These factors include socio-economic status, educational status of patients, employment support, spousal support, psychosocial challenges and financial stability. This review aimed to identify the determinants of QOL in Indian breast cancer patients. The scope of predictive analytics in the domain has also been discussed.
  Gopal Krishan , Santosh Kumar Shukla , Prakash Bhatt , Rajesh Kumar , Ruchi Tiwari , Yashpal Singh Malik and Kuldeep Dhama
  The present investigation was undertaken to assess the role of a polyherbal immunomodulator with additional elements (Immon) against the chicken infectious anemia virus (CIAV) infection. A total of 60 broiler chicks (day old age) were divided into three groups (n= 20) and vaccinated against Newcastle disease (ND). The group I chicks were kept as healthy control while group II and III chicks were infected with 1 ml CIAV (104.5 TCID50/0.1 ml) per chicken intramuscularly. Group III chicks were supplemented with Immon (1 ml / 10 birds in the drinking water) for 21 days. Subsequently, chicks of all three groups were monitored for hematological (Hb, PCV, TEC, TLC and DLC) and biochemical parameters (AST, ALT, ALP and uric acid) along with ND antibody titers, organ: body weight ratios, and mean live body weight at on 7th, 14th, 21st, 28th and 35th day of the experiment. At 7 - 24 days of CIAV infection, the group II birds showed a significantly lower count of erythroid and myeloid cells; increase in enzyme activities and uric acid; decline in mean live body weight and organ: body weight ratios of lymphoid organs, and decline in ND antibody titers. However, at these day intervals the CIAV immunosuppression was less severe in Immon supplemented chicks which showed significantly (P<0.05) higher values of all the test parameters as compared to virus control group II chicks. Thus, the present findings support that Immon is an effective immunomodulating agent in CIAV affected birds, reduces pathogenicity of the virus, ameliorate the depressed immune responses and protects the virus induced adverse effects on growth performances.
  Ashwani Tapwal , Rajesh Kumar , Nandini Gautam and Shailesh Pandey
  Trichoderma viride can thrive in diverse environmental conditions as aggressive colonizers of soil and the roots of plants and act as natural bioagent to protect plants from infection by soil-borne fungal pathogens. Laboratory experiments were conducted to test the possibility of combining fungicides and botanicals with Trichoderma viride to work out their compatibility to devise a suitable integrated management of soil borne plant diseases. Five fungicides viz., dithane M-45, ridomil, captaf, blue copper, bavistin and five botanicals viz., Parthenium hysterophorus, Urtica dioeca, Cannabis sativa, Polystichum squarrosum and Adiantum venustum were evaluated at different concentration. Among fungicides only captaf and blue copper had recorded compatiblility to some extent with T. viride. While the water extracts of the tested botanicals were quite compatible with Trichoderma except for C. sativa, which have some inhibitory effect on the growth of pathogens. Present investigation suggests that compatible fungicides and botanicals can be used with Trichoderma in an IDM package to control soil borne plant pathogens.
  Vijai Lakshmi , Rajesh Kumar , Kartikey Pandey , Bhawani Shanker Joshi , Raja Roy , Kunnath Padamnabham Madhusudanan , Priti Tiwari and Arvind Kumar Srivastava
  A new steroidal saponin, chloragin (1), was isolated and characterised from the aerial part of Chlorophytum nimonii. The structure of chloragin (1) was established as tigogenin-3-O-agr-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 4)-β-D-xyloopyranoside on the basis of detailed chemical and spectral evidence. The saponin showed potent antihyperglycaemic and antidyslipidaemic activities in albino rats.
  Rajesh Kumar
  Waveguide to cavity coupled systems frequently need coupling coefficient adjustments after fabrication. The change in coupling is achieved either by changing the dimensions of iris mechanically or introducing a matching post. We propose a novel coupling coefficient tuning method based upon iris rotation. The coupling can be varied over a wide range without changes in the dimensions of the iris or an extra matching post.
  Kuldeep Dhama , Amit Kumar Verma , S. Rajagunalan , Amit Kumar , Ruchi Tiwari , Sandip Chakraborty and Rajesh Kumar
  Listeriosis is a disease that causes septicemia or encephalitis in humans, animals and birds. Although, the disease is rare and sporadic in poultry but if occurs then causes septicemia or sometimes localized encephalitis. Occasionally, the disease is seen in young chicks and the causative agent, like in humans and animals, is Listeria monocytogenes. The organism is capable to infect almost all animals and poultry; however, outbreaks of listeriosis are infrequent in birds. It is widely distributed among avian species and chickens, turkeys, waterfowl (geese, ducks), game birds, pigeons, parrots, wood grouse, snowy owl, eagle, canaries, which appear to be the most commonly affected. Chickens are thought to be the carriers of Listeria and also the prime reservoirs for the infection and thus contaminate the litter and environment of the poultry production units. Listeriosis is often noticed along with other poultry diseases such as coccidiosis, infectious coryza, salmonellosis, campylobacteriosis and parasitic infections, signifying the opportunistic nature of the organism. Intestinal colonization of poultry and the presence of L. monocytogenes in feces represent a potential source of the organism for listeriosis in ruminants. Man gets infection from raw broiler meat due to Listeria contamination and unhygienic conditions of the processing area, rather than acquiring direct infection from birds. With the changing food habits of the people, the health consciousness is also increasing and since listeriosis has now been recognized as an emerging food borne zoonoses. Therefore, this review has been compiled to make aware the poultry producers and the consumers of poultry meat/products regarding the importance of the disease and its public health significance.
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