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Articles by Rajdeep Chakravarty
Total Records ( 1 ) for Rajdeep Chakravarty
  Sanjukta Manna , Rajdeep Chakravarty , Buddhadeb Manna and Amal Bhattacharya
  Considering the invasion strategy of the Leishmania parasite the molecules present on the cell surface of promastigotes are of paramount importance as the parasite membrane antigens are the interface between the parasite and its vertebrate and insect hosts. Their topography and receptor interactions with host cell decide the acceptability, survival, multiplication, pathogenesis or killing of the parasite in the host. Gamma radiation had interesting effects on living cells and proteins, allowing new epitopes to express but parasites presented unequal radiosensitivity, related to their genome organization. After exposure to gamma radiation from Co60 source, Leishmania donovani undergo profound changes in ultrastructure, microviscosity, protein profile and carbohydrate residues of plasma membrane. Upto 20 krad, the membrane integrity was maintained but above this dose the microtubules showed chracteristic fluence dependent changes in the number of protofilaments upon gamma radiation. Agglutination progressively decreased from nonirradiated to irradiated promastigotes. The most prominent epitopes at 53 and 66 kDa were expressed at 10 and 20 krad irradiated parasites surface. It was also indicated that 20 krad was the limiting dose at which cell can survive and compensate for altered conditions by a process known as homeoviscous adaptation so it can remain in the fluid phase even as the environment changes.
 
 
 
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