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Articles by Radhakrishnan Surendra Kumar
Total Records ( 2 ) for Radhakrishnan Surendra Kumar
  Sujith Sugathan , Aseer Manilal , Joseph Selvin , Akbar Idhayadhulla , Radhakrishnan Surendra Kumar and M.V.N. Panikkar
  Seaweed-associated marine bacteria were recognized as a potential source of antimicrobial compounds. In the present study, a total of 27 epiphytic bacteria were isolated from four species of seaweeds collected from the Kollam coast (Indian Ocean) were investigated for antagonistic activity by cross streak method. Of the 27 bacterial isolates, 4 strains inhibited the growth of at least one shrimp vibrio pathogen tested. The active strains were further subjected to agar well diffusion assay. The result indicates that among the four seaweed isolates, SWI-24 strain exhibited highest spectrum of activity against all the tested shrimp pathogens. The molecular characterization based on partial 16S rRNA sequence revealed that the active isolate SWI-24 was Pseudoalteromonas sp. The efficient antagonistic potential exhibited by the SWI-24 against pathogenic shrimp bacteria may further reflect the potential use of seaweed-associated bacteria in managing the shrimp/fish disease.
  Akbar Idhayadhulla , Radhakrishnan Surendra Kumar , Abdul Jamal Abdul Nasser and Aseer Manilal
  The compounds of 2,2'-[(3,5-dimethyl-1H-pyrrole-2,4-diyl) dicarbonyl]dihydrazine carboxamide(2), 2,2’-[(3,5-dimethyl-1H-pyrrole-2,4-diyl)dicarbonyl]dihydrazine carbothioamide(3), 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazine carboxamide(5) and 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine -3,5-diyl]dicarbonyl}dihydrazine carbothioamide (6) were synthesized from hydrazinolysis method and synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds were screened for antimicrobial and anticancer activities. Evaluation of antibacterial, antifungal activity showed that the compounds exhibited better results than reference drugs. The newly synthesized compounds have been screened for preliminary anticancer activity against HepG2(Liver), Hela(Cervical), MCF-7(Breast) cancer cells. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
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