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Articles by R.T. Narendhirakannan
Total Records ( 2 ) for R.T. Narendhirakannan
  R.T. Narendhirakannan , S. Subramanian and M. Kandaswamy
  In the present study, anti-oxidant effect of ethanolic extract of Cleome gynandra leaves on the components of immune system in adjuvant induced experimental rats was evaluated. Freund’s Complete Adjuvant (FCA) was used to induce arthritis in experimental rats. Levels of Lipid peroxides (LPO) and activities of Superoxide dismutase (SOD), catalase, Glutathione peroxidase (GPx) and reduced glutathione (GSH) were evaluated in the lymphocytes, spleen and thymus of control and experimental rats. Further, the levels of ROS such as, hydroxy radicals, superoxide radicals and hydrogen peroxide (H2O2) were also measured in spleen, thymus and lymphocytes in experimental rats. Paw volume was also measured in the experimental animals. A significant increase in the levels of LPO, ROS and decreased activities of antioxidant enzymes in arthritic rats were observed. The above changes were reverted to near normal in Cleome gynandra leaf extract treated rats. The biologically active compounds such as, terpenes, flavonoids, saponins, steroids, phenolic compounds, alkaloids, carotenes, vitamins, minerals etc., which are present in C. gynandra leaves might be responsible for its anti-oxidant properties. The results demonstrated that anti-oxidant and anti-arthritic potent of C. gynandra leaves.
  R.T. Narendhirakannan , S. Subramanian and M. Kandaswamy
  The present study was aimed to evaluate the anti-inflammatory potential of Cleome gynandra leaf extract on both acute (carrageenan induced paw edema) and chronic (cotton pellet granuloma) experimental inflammatory models induced in rats. The effect of C. gynandra on adjuvant induced arthritis was also evaluated. The extract at a dose of 150 mg kg-1 body weight was found to possess significant anti-inflammatory activity in all the experimental models and the results were comparable with indomethacin, a standard reference drug. The extract significantly decreased the carrageenan induced paw edema and cotton pellet granuloma. The increased activities of acid and alkaline phosphatase activity and decreased serum level albumin in cotton pellet granulomatous rats were reverted back to near normal levels after treatment with the extract. The extract significantly decreased the lipid peroxide (LPO) content of exudates, liver and spleen and the activity of γ-glutamyl transpeptidase in the exudates of cotton pellet granuloma. Moreover, C. gynandra also significantly suppressed the development of chronic arthritis induced by Freund`s complete adjuvant. These results demonstrated that the ethanolic extract of Cleome gynandra possess anti-inflammatory activity on both acute and chronic inflammation.
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