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Articles by R.S. Singh
Total Records ( 1 ) for R.S. Singh
  Mushtaq Ahmad , R.S. Singh , Zahoor Ahmad Wafai and M.G. Bamnote
  Background: Aloe vera, is a natural hepatoprotective agent used alone or an ingredient of number of medicinal preparations in Indian traditional medicine (Ayurveda) and in folk medicine across the globe for different liver ailments. However, considerable number of them lacks scientific proof for their claims. Hence, Aloe vera was evaluated for its protective effect against carbon tetrachloride (CCl4) induced liver toxicity in wistar albino mice and rabbits. Materials and methods: Two species of the animals (rabbit and mice) were used to evaluate Aloe vera for its effects on histopathology, biochemistry and mortality induced by carbon tetrachloride in experimental setup. The animals were divided into main three groups (GI, GII and GIII) of eighteen animals each. Each group was further divided into three subgroups of six animals each. Depending upon the treatment protocol, subgroup ‘a’ received linseed oil as control. Subgroup ‘b’ received CCl4. While as subgroup ‘c’ received extract of Aloe vera prior to CCl4 administration. Results: Animals pretreated with Aloe vera and subsequently treated with CCl4 showed significant reduction in histopathological changes (p<0.05), biochemical changes (p<0.05) and mortality rate (p<0.05) in comparison to the animals treated with CCl4 alone. Conclusion: This study reveals the hepatoprotective effect of Aloe vera against CCl4 induced liver toxicity.
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