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Articles by R.O. Arise
Total Records ( 3 ) for R.O. Arise
  R.O. Arise , S.O. Malomo and O.A. Bolarinwa
  Anti-malarial property and toxicity of methanolic extract of leaves of Tithonia diversifolia and Morinda lucida were investigated in mice and rats, respectively. Percentage parasitemia and chemosuppresive effect of the extract on Plasmodium berghei infected mice were used to assess anti-malarial property while toxicity was evaluated by measuring the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and some selected tissues as well as evaluation of some hematological parameters, serum electrolytes, urea and creatinine in rats. The extract at 200 mg kg-1 b.wt. showed significant (p<0.05) chemo suppressive effect following five days administration in P. berghei established infection. There was a significant decrease (p<0.05) in the liver, kidney and serum activities of ALT following 7 and 14 days administration of the extract. Similar trends were observed in liver and serum ALP and liver AST. However, there was a significant increase (p<0.05) in kidney and serum AST activity for both periods of administration except for the significant decrease (p<0.05) in the kidney following the 14 days administration. The white blood counts showed a significant decrease (p<0.05) following administration of T. diversifolia for 7 and 14 days and M. lucida for 14 days while administration of both extract for 14 days revealed a significant increase (p<0.05) in platelet counts. Serum bicarbonate, chloride, sodium, potassium and urea decreased significantly (p<0.05) following administration of the extract for 7 and 14 days. This result therefore suggests that, methanolic extract of T. diversifolia and M. lucida possess considerable anti-malarial property but may potentiate some level of toxicity especially if administration is prolonged.
  R.O. Arise , A.A. Akintola , J.B. Olarinoye and E.A. Balogun
  The study was carried out to investigate effects of administration of aqueous extract of Nauclea latifolia stem on lipid profile and some liver and kidney parameters of rat. Thirty rats were grouped into five. Each group consisting of six rats each. Group 1 served as the control and was administered 2 mL distilled water. The remaining groups were administered 200, 400, 600 and 800 mg kg-1 b.wt. of aqueous extract of Nauclea latifolia stem, respectively. Administration lasted for twenty eight days during which three rats from each group were sacrificed twenty four hours after administration on the fourteenth day and the remaining, twenty eighth day. Liver, kidney and blood were collected and alkaline phosphatase, alanine aminotransferase, aspartate amino transferase, urea, creatinine, malondialdehyde level as well as lipid profile evaluated. The results showed a significant (p<0.05) concentration dependent decrease in total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and increase in low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) at both periods. Similar results were obtained in serum concentration of creatinine and urea with TC and HDL-C. There was significant concentration dependent reduction (p<0.05) in liver and kidney alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase activities with a corresponding significant increase (p<0.05) in their serum activities. This revealed a time and concentration dependent hepatotoxic and nephrotoxic potentials of the aqueous extract of Nauclea latifolia stem.
  A.K. Arise , R.O. Arise , A.A. Akintola , O.A. Idowu and O.C. Aworh
  The aim of this study was to investigate the microbial load and evaluate the nutritional content and sensory property of traditional sun dried okra (“orunla” - Yoruba, Nigeria). Samples were purchased from four different markets at different time in South-western Nigeria. Microorganisms present in the samples were analyzed on nutrient agar, potato dextrose agar and malt extract. Proximate evaluation of the sun dried okra was also carried out to determine the protein, ascorbic acid, ash and crude fibre contents. Nutritional evaluation revealed considerable amount of measured nutrient without significant difference (p>0.05) inspite of the time and place of purchase. Sensory evaluation of the samples showed that they were generally acceptable to a taste panel. Microbial study identified Staphylococcus aureus, Aspergillus niger, Aspergills tamari, Fusarium compactum, Rhizopus nigricans and Bacillus lichiniforms as some of the microorganisms present in the sun-dried vegetable. This study thus, suggested that sun-dried okra could be consumed but when processed under control microbial condition.
 
 
 
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