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Articles by R.K. Sari
Total Records ( 2 ) for R.K. Sari
  Z. Saleh , E.A.M. Zuhud and R.K. Sari
  Rhizanthes deceptor is a species that found only in Sumatera, Indonesia. Crude ethanolic extract of Rhizanthes deceptor and it’s host, T. papillosum papillosum were examined for their phytochemical properties and antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical qualitative analysis showed that all the extracts, containing alkaloid, phenolic and flavonoid. Triterpenoid detected in bud extract and root extract, saponin detected in root and stem extract and steroid only detected in stem extract. The result showed high level of total phenolic content from all the extract with their value are 431.52, 323.93 and 271.38 mg GAE/g from bud extract of R. deceptor, root and stem of T. papillosum, respectively. Presence of detected secondary metabolites thought to contribute to antioxidant activity of this extract. Antioxidant activity of the plants showed that bud extract of R. deceptor and root and stem extract of T. papillosum had fairly high DPPH antioxidant activity with IC50 are 32, 22 and 35 μg mL–1, respectively. The result of antioxidant activity test indicates that R. deceptor and T. papillosum as, natural sources of antioxidant.
  W. Syafii , R.K. Sari , U. Cahyaningsih and L.N. Anisah
  Background and Objective: This study identify the fraction contents from ethanol extract of Strychnos ligustrina Blume wood, their antimalarial activities and chemical compound of the antimalarial active fraction. Methodology: The ethanol extract was obtained from maceration with n-hexane, ethyl acetate and ethanol successively. The ethanol extract was fractionated using vacuum liquid chromatography column with combination of chloroform and methanol as eluent. These fractions were tested for their antimalarial properties by using in vitro against Plasmodium falciparum. The active antimalarial fraction was then chemically analyzed by using gas chromatography mass spectrometry instrument. Results: The fractionation of ethanol extract resulted in six fractions, namely F1, F2, F3, F4, F5 and F6 with fraction contents at 2.48, 0.89, 14.28, 22.34, 25.57 and 30.34%, respectively. The antimalarial bioassay test showed that F3 and F4 were very active with IC50 (1.99 and 0.39 μg mL–1, respectively) F1 was active with IC50 (81.04 μg mL–1) while, F2, F5 and F6 were inactive with IC50 (1581.60, 1123.22 and 81.04 μg mL–1, respectively). Gas chromatography mass spectrometry instrument detected the F3 contains alkaloids such as (phenylbenzo[f]1,7 naphthyridin-5-one (11.67%), 4-methyl-5-[3-trifluoromethylphenoxy]-6-methoxy-8-nitroquinoline (5.21%) and phenolic compounds (coniferol 8.10%). The F4 is dominated by furan compounds (hydroxymethyl furfural 19.43%), phenolic (laminitol 19.43%), fatty acid (9,11-octadecadiynoic acid, 8-hydroxy-methylester 6.34%) and alkaloid (brucine 6.13%). Conclusion: Extractive substances of S. ligustrina wood were very potential sources for natural antimalarial drugs. Fractionation ethanol extract of S. ligustrina wood produced fraction F3 and F4 were very active in inhibiting the growth of P. falciparum. These results strongly suggested that F3 and F4 of S. ligustrina wood were potential sources for antimalarial agents. For future development, it is neccesary for further studies to obtain the antimalarial active compounds from fraction F3 and F4 as an alternative new malaria drugs as well as material alternative drug combinations with artemisinin to get the optimal treatment of malarial.
 
 
 
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