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Articles by R.K. Devarakonda
Total Records ( 2 ) for R.K. Devarakonda
  R.N.R. Anreddy , M. Porika , N.R. Yellu and R.K. Devarakonda
  The present study was designed to evaluate the hypoglycemic and hypolipidemic activity of methanol extract of Trianthema portulacastrum Linn. whole plant in normal and alloxan-induced diabetic rats. Alloxan was used to induce diabetes in rats and the blood glucose, lipid levels were estimated using commercial kits available in the market. The methanol extract of T. portulacastrum was administered for 7 days to normal and alloxan induced diabetes rats at a dose of 100, 200 and 300 mg kg-1. The extract produced significant reduction (p<0.001) in blood glucose at a doses of 100, 200 and 300 mg kg-1 in normal and diabetic rats. It also produced beneficial effects on the lipid profile in normal as well as alloxan induced diabetic rats at the end of the treatment period (7th day). The methanol extract of Trianthema portulacastrum produced a dose dependent hypoglycemic, antihyperglycemic and hypolipidemic activity in rats and were comparable with standard oral hypoglycemic agent, glibenclamide.
  R.N.R. Anreddy , N.R. Yellu , R.K. Devarakonda and H. Vurimindi
  The aim of the present study was to evaluate the in vitro toxicity of two Multi Wall Carbon Nanotubes (MWCNT) on human hepatocytes (Hep G 32 cell lines). The toxic effects of carbon nanoparticles were analyzed after 24 h of incubation with different cell lines using MTT assay and also estimated the levels of Lactate Dehydrogenase (LDH) (that is leakaged into the media). The results of the LDH estimation demonstrated that exposure of multi wall carbon nanotubes to hepatocytes (Hep G 32) for 24 h resulted in concentration-dependent increase in LDH leakage and exhibited a significant (p<0.05) cytotoxicity at a concentration range of 3-50 μg mL-1. The TC50 or IC50 values (toxic concentration 50 i.e., concentration of particles inducing 50% cell mortality) of two nanoparticles (1) were found in the range of 36.99-37.15 μg mL-1, (2) were less than that of quartz (known toxic agent, 39.85 μg mL-1), indicating their cytotoxicity of carbon nanoparticles.
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