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Articles by R.I. Ozolua
Total Records ( 4 ) for R.I. Ozolua
  E.E. Bafor , M. Nwiko , E.K.I. Omogbai , R.I. Ozolua and Z.A.M. Nworgu
  The effect of the aqueous stem-bark extract of Ficus exasperata (ASE) was studied on oxytocin- and acetylcholine-induced uterine contractions in uterine preparations isolated from non-pregnant Sprague-Dawley rats in oestrus. Preliminary phytochemical analysis was also performed. There were no statistically significant increases in the concentrations of oxytocin and acetylcholine required to elicit 30 and 50% of maximum response (EC30 and EC50, respectively) in the presence of the extract. Salbutamol and atropine, however, significantly inhibited the effects of oxytocin and acetylcholine, respectively. Phytochemical analysis revealed the presence of alkaloids, tannins and saponin glycosides. These results indicate that ASE possesses no inhibitory effect on the non-pregnant rat uterus as claimed by traditional healers.
  R.I. Ozolua , E.E.I. Omogbai and A.B. Ebeigbe
  The observation that chronic oral potassium supplementation could cause a decrease in blood pressure in normotensive rats led to the design of the present study aimed at understanding the nature of vascular reactivity to some drugs. Responses of aortic ring preparations were obtained from two groups of Wistar rats: One given normal feeds and tap water (control) and the other given normal feeds and 0.75% KCl solution for 5 weeks (potassium-adapted). Isometric contractions were measured in rings exposed to noradrenaline (NA), 5-HT, KCl and CaCl2 while relaxations were measured in the presence of acetylcholine (ACh), sodium nitroprusside (SNP) and Levcromakalim. Results show significant decreases (p<0.05) in both pD2 and Emax values for NA and 5-HT in rings from K-adapted rats. In the case of KCl, although the pD2 values were significantly different, the Emax were the same. Maximum responses to CaCl2 were not significantly altered but threshold concentrations were significantly raised in rings from K+-adapted rats. Following NA pre-contraction, responses to ACh in endothelium-intact vessels did not change but relaxation was significantly enhanced in endothelium-denuded vessels from K+-adapted rats. Responses to SNP and levcromakalim were significantly enhanced and were only partially reversed by tetraethylammonium (TEA). The results suggest the non-involvement of endothelial nitric oxide but suggest the possible roles of potassium-channels in the altered vascular reactivity in aortic rings from normotensive K+-adapted rats.
  N.P. Okolie , R.I. Ozolua and D.E. Osagie
  The effects of chronic exposure to crude acetylene on some biochemical and haematological indices were studied in New Zealand White rabbits exposed to inhalation of 58,000 ppm crude acetylene for 10 min at 12 h intervals for 3 weeks. The treatment provoked significant elevation of aspartate and alanine transaminases in plasma of test rabbits relative to controls (p<0.001; p<0.005). In addition, catalase activity was significantly depressed in the heart, liver and kidney tissues (p<0.005), while superoxide dismutase was significantly raised in heart tissue (p<0.008). Packed cell volume was significantly lower in rabbits exposed to crude acetylene (p<0.05), while marginal decreases were seen in the other haematological parameters investigated. These results suggest that unlike pure industrial acetylene, crude acetylene may have deleterious effects on vital organs and blood constituents. Thus the use of in situ generated acetylene by welders may be hazardous to health.
  G.B.S. Iyalomhe , E.K.I. Omogbai and R.I. Ozolua
  The objective of this prospective, randomised, open, single-centre study was, therefore, to determine the antihypertensive and biochemical effects of 25 mg oral hydrochlorothiazide and 40 mg oral furosemide given once daily for 21 days to 40 patients with mild to moderate uncomplicated essential hypertension aged between 32 and 80 years and 40 age and sex-matched normotensive controls while on their usual diet. Urine volume, systolic and diastolic BP evaluated as Mean Arterial Pressure (MAP) as well as urine and serum sodium (Na+), potassium (K+) and chloride (Cl) were assessed before and during treatment. Both drugs significantly increased diuresis (p< 0.0001); lowered MAP (p< 0.0001) and increased urine K+ (p< 0.001) in the hypertensive subjects compared to controls. It is concluded that once daily 25 mg of hydrochlorothiazide and 40 mg of furosemide are effective in lowering BP as monotheraphy in Nigerians with mild to moderate hypertension and they are associated with some adverse biochemical effects including K+ depletion.
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