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Articles by R.G. Ahmed
Total Records ( 2 ) for R.G. Ahmed
  R.G. Ahmed
  Because of the temperature is one of the most encountered stressful factors in the environment, it was deemed important to survey the literature for reports on high temperatures or hyperthermia exposure durations at which biological effects occur. Since that time, several method of heating the entire body have evolved, including the artificial induction of fever, the wrapping of an anesthetized patient in plastic and dipping them in hot wax and heating the blood supply. The aim of this review was to determine the changes in tissue temperature and the duration of this effect. In general, the higher the temperature or the longer the hyperthermia, the greater the chance for observing a perturbation to the biological effects. It appears reasonably well established that, short exposure to sharply-elevated temperatures result in a protective effect against further thermal insult; the generation of heat shock proteins by cells coincides with the onset of such "thermal protection". It can be concluded that, thermal damage increases as the time at an elevated temperature increases.
  Osama M. Ahmed , M. Bahgat and R.G. Ahmed
  The normal monoamine [norepinephrine (NE), epinephrine (E), dopamine (DA) and serotonin (5-HT)] contents and cholinestrase (chE) activity were significantly and gradually increased with age progress between postnatal days 7 and 21 in cerebrum, cerebellum, medulla oblongata and spinal cord of rat newborns. The daily exposure of the newborns to 40±1°C for 2 h induced deteriorated effects and the withdrawal period of 7 days failed to return these altered variables to normal levels. On the other hand, the high temperature exerted its most potent decreased effect on monoamine contents at 21 days old. This decrease may be attributed to the elevated activity of monoamine oxidase and/or the decreased activity of the key enzymes responsible for monoamine synthesis. The chE activity exhibited different effects in the tested CNS regions as a result of high temperature exposure; the enzyme activity was decreased markedly at days 7, 14 and 21 in cerebellum and medulla oblongata and lowered only at days 7 and 14 in cerebrum and at day 14 in spinal cord. The subsequent withdrawal for 7 days beyond day 21 produced marked weakening of effect of high temperature exposure on monoamine contents in all examined CNS regions except NE and 5-HT contents in cerebellum and DA level in medulla oblongata. In spite of this attenuation, the values recorded in the withdrawal group were still significantly lower than the normal levels. On the other hand, the chE activity became more deleteriously affected at day 28 in the treated CNS regions except in the medulla oblongata where it was profoundly ameliorated after the withdrawal period.
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