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Articles by R.B. Ashorobi
Total Records ( 6 ) for R.B. Ashorobi
  S. Umukoro and R.B. Ashorobi
  The anti-inflammatory and membrane-stabilizing effects of an aqueous leaf extract of Eupatorium odoratum was investigated in this study. The effect of the extract on acute inflammation was studied in carrageenin-treated rats. The anti-inflammatory activity of E. odoratum was further assessed in rats subjected to sub-chronic inflammatory conditions induced by formaldehyde. The membrane-stabilizing property of the extract was studied using its ability to reduce the levels of haemolysis of rat Red Blood Cells (RBC) exposed to hypotonic solution. The results of the study showed that the extract (100-400 mg kg-1, p.o) possess anti-inflammatory property, as it significantly reduced oedema formation induced by the phlogistic agents in rats. At a concentration range of 1.0-2.0 mg kg-1, the extract offered significant protection of RBC against the haemolytic effect of hypotonic solution, an indication of membrane-stabilizing activity. It appears that the membrane-stabilizing effect exhibited by Eupatorium odoratum might be playing a significant role in its anti-inflammatory activity.
  A.I. Oreagba and R.B. Ashorobi
  The aim of present study was to investigate the effect of retinol on the efficacy of chloroquine and dihydroartemisinin against Plasmodium yoelii nigeriensis infected mice. Sixty Swiss albino mice of either sex and average weight of 18-25 g were inoculated with Plasmodium yoelii and divided into 5 treatment groups: retinol alone, chloroquine alone, chloroquine and retinol, dihydroartemisinin alone, dihydroartemisinin and retinol and control group (retinol vehicle). Treatment was started on the fifth day (post inoculation) and continued for 5 consecutive days. The level of Malondialdehyde (MDA) in the treatment group was also measured to determine the extent of lipid peroxidation. The result of the study showed that retinol increased the antiplasmodial effect of chloroquine while antagonizing that of dihydroartemisinin. The lipid peroxidation assay also showed that retinol reduced the extent of oxidative stress when combined with dihydroartemisinin while not having any significant effect on lipid peroxidation when combined with chloroquine. The co-administration of retinol may enhance the activity of chloroquine but reduce the antimalarial potency of artemisinin.
  I.O. Ishola and R.B. Ashorobi
  This study presents the results of the phytochemical screening, acute toxicity testing and anti-stress potential of aqueous root extract of Cnestis ferruginea in mice and rats. The forced swimming endurance test, anoxic tolerance tests and immobilization stress-induced gastric ulcer were utilized as models for the evaluation of the anti-stress property of C. ferruginea. The results from phytochemical tests showed the presence of alkaloids, flavonoids, saponins and glycosides as the major constituents of the root extract of C. ferruginea. The acute toxicity test showed a wide margin of safety with a median lethal dose (LD50 of 3.6570 g kg-1) in mice. In the forced swimming test, C. ferruginea at a dose range of (300-500 mg kg-1, p.o) significantly decreased the duration of immobility in a dose-related manner. These results showed that the extract is a potential anti-stress agent. In the anoxic tolerance test, the extract prolonged the mean time (min) before convulsion in mice in a dose-dependent manner. Also in the immobilization stress-induced gastric ulcer, the extract prevented gastric ulcer formation in rats immobilized and subjected to stress (cold) at 4°C for 2 h after pretreatment with the aqueous root extract. This further confirmed the anti-stress potential of the extract. In conclusion, the root extract of C. ferruginea is a potential anti-stress agent.
  B.A.S. Lawal , R.B. Ashorobi and O.O. Adeyemi
  The commonly used antituberculosis (antiTB) drugs; pyrazinamide (PZA), isoniazid (INH), ethambutol (ETB) and rifampicin (RMP) were administered to albino rats for the purpose of investigating the toxic consequences of combination therapies. The drugs were evaluated by simulating the normal clinical dosage and a 24 week gavage studies of standard therapy with antituberculosis drugs in albino rats without disease were carried out. The doses employed were: Isoniazid, 5 mg kg-1; rifampicin, 10 mg kg-1; ethambutol, 20 mg kg-1 and pyrazinamide, 25 mg kg-1. The effect of clinically equivalent antiTB regimen and established oxidant drug, aminopyrine, on membrane lipid peroxidation and osmotic fragility in rat red cells was examined. The regimen showed evidence of protection against hemolysis both in vitro and in vivo although there are evidences of distorted erythrocyte membranes which appeared to be approaching a star-shaped configuration and an enhanced antihemolytic effect in hypotonic saline solution. Since star-shaped erythrocytes have been shown to be devoid of ATP, this may have consequences on the physiological function of the red blood cells.
  S. Umukoro , R.B. Ashorobi and E.E. Essein
  This study reports on the anticonvulsant and anxiolytic effects of two well-known calcium channel antagonists, verapamil and nifedipine in mice. The anticonvulsant effect of these drugs was screened utilizing strychnine animal seizure model. The anxiolytic effect of these compounds was assessed using elevated plus maze paradigm. The results of the study showed that verapamil (5-20 mg kg-1, i.p) and nifedipine (5-10 mg kg-1, i.p) exhibited anticonvulsant activity as evidenced by their ability to prolong the onset of seizures produced by strychnine (1 mg kg-1, i.p) in mice. Verapamil (20 mg kg-1) offered 100% protection against convulsions or death induced by strychnine. Similar effects were observed in animals pretreated with 10 mg kg-1 of nifedipine. In the anxiolytic test, verapamil, but not nifedipine significantly (p<0.05) modified the number of entries in a similar manner to diazepam in the elevated plus maze paradigm. Taken together, these findings suggest that verapamil possess both anticonvulsant and anxiolytic effects, whilst nifedipine only exhibited anticonvulsant activity in mice.
  A.I. Oreagba and R.B. Ashorobi
  The present study was conducted to evaluate the antiplasmodial activity of retinol on chloroquine-sensitive Plasmodium berghei berghei infection in mice. Albino mice weighing 18-25 g where treated with retinol (50-200 mg kg-1) in a set of experiments to investigate chemotherapeutic and prophylactic effect against Plasmodium berghei berghei infection in mice. Treatment in one of the chemotherapeutic groups continued throughout the study period. Retinol demonstrated a mild dose dependent schizontocidal effect on early and established infection. This effect became stronger on chronic administration but it also produced toxic manifestations and eventual death in most of the animals. Retinol also demonstrated a prophylactic effect by significantly delaying the onset of infection. The repository activity of retinol was however lower than that of the standard drug (Pyrimethamine-1.2 mg kg/day). Retinol possesses antiplasmodial activity especially during chronic administration thus suggesting that it might have a role in malaria control. Further studies in the area of its structural activity relationships are needed to justify this assertion.
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