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Articles by R.A. Magaji
Total Records ( 2 ) for R.A. Magaji
  R.A. Magaji , M.I.A. Saleh , M.G. Magaji and I. Buhari
  The seeds of Mucuna pruriens commonly called Velvet or Mucuna beans have extensively been used in Brazilian and Indian traditional Ayurvedic medicine for many ailments. Exploratory behaviors are affected by drugs based on the types of neurotransmitter they interact with in the brain. Diazepam-induced sleep test in four groups of 6 mice treated with intraperitoneal distilled water (10 mL kg-1), 600, 300 and 150 mg kg-1; hole board test for exploratory behavior in 5 groups of mice treated with intraperitoneal distilled water (10 mL kg-1), diazepam (1.5 mg kg-1), 600, 300 and 150 mg kg-1 of Mucuna pruriens aqueous seed extract respectively were carried out. The studies showed that Mucuna pruriens significantly and dose-dependently prolonged the duration of diazepam-induced sleep which suggests that it possess sleep inducing property. The ability of the extract to significantly reduce the number of head dips in the hole-board test corroborates the CNS depressant potential of the plant extract. It is concluded that Mucuna pruriens may be a remedy in some CNS disorders.
  M.G. Magaji , Y. Yakubu , R.A. Magaji , A.M. Musa , A.H. Yaro and I.M. Hussaini
  Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg-1) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice. The CNS depressant effect was also evaluated using ketamine-induced sleep test mice. The extract at the highest dose tested (100 mg kg-1) significantly reduced the apomorphine (1 mg kg-1)-induced stereotypic climbing behavior after 30 min. Similarly, haloperidol (2 mg kg-1), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, haloperidol (2 mg kg-1) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total ketamine-induced sleep duration at doses of 50 and 100 mg kg-1. These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of mental illness.
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