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Articles by R.A. Shehu
Total Records ( 3 ) for R.A. Shehu
  M.T. Adewumi , C.H. Njoku , Y. Saidu , M.K. Abubakar , R.A. Shehu and L.S. Bilbis
  In this study serum copper, chromium and manganese were estimated in 90 diabetic patients attending the outpatient clinic of the Federal Medical Centre, Katsina, an ancient city in North-western Nigeria and the results compared to those of apparently healthy, non-diabetic volunteers of comparable age and social status. Serum glucose level of the diabetic subjects (13.91±2.87 mmol L-1) was significantly (p<0.05) higher that the value obtained for the non-diabetic subjects (4.34±0.11 mmol L-1). The serum levels of Cr (0.19±0.05 μg L-1), Cu (0.42±0.18 μg L-1) and Mn ((1.12±0.24 μg L-1) were significantly (p<0.05) lowered in diabetic subjects. About 75% of the diabetic subjects in the study area had deficient serum levels of these metals. These results suggest that the diabetic patients in the study area have low serum levels of some antioxidant mineral elements. These observations may be an indication that the diabetic subjects are predisposed to increased oxidative onslaught.
  Y. Saidu , M. Lawal , S.A. Isezuo , R.A. Shehu , D.M. Sahabi and L.S. Bilbis
  This research studied the hypoglycaemic effect of aqueous leaf extract of Albizzia chevalieri in alloxan-induced diabetic albino rats, using activity-guided fractionation. Preliminary elucidation of the mechanism of hypoglycaemic activity was also studied. The crude aqueous leaf extract of the plant (100 mg kg-1 body weight) reduced blood glucose levels of both the diabetic and normal rats by about 30%. The hypoglycaemic agent(s) were fractionated in the hexane fraction of the aqueous extract and partitioned in the second elution fraction (H2) by column chromatography. Thin layer chromatography of H2 gave a single spot with water as the mobile phase. The preliminary results of the mechanism of action indicated that the extract did not affect the in vivo digestion of carbohydrate or intestinal absorption of glucose. It however caused significant (p<0.05) increase in the hepatic and extrahepatic glycogen store. Phytochemical screening of the crude extract indicated the presence of saponins, flavonoids, tannins, terpenes, steroids, balsams, glycosides and alkaloids. UV/visible spectral studies of H2 indicated a λmax of 320 nm. These results suggest that the hypoglycaemic effect of the extract is as a result of induction of glycogenesis.
  M.G. Abukakar , A.N. Ukwuani and R.A. Shehu
  The effects of graded doses of Tamarindus indica pulp extract on the haematological, toxicological and histopathological indices in rats were evaluated. Hematological parameter was determined using micro-hematocrit method and Neubauer hemocytometer counting chamber. The haematological parameters (PCV, WBC, Lymphocytes and Monocytes) of the treated groups showed no significant difference (p< 0.05) when compared with the control. Although there was a significant increase (p< 0.05) (p< 0.01) in the nuetrophils in group 3 and 4 and decrease (p< 0.05) (p< 0.01) in eosinophils at group 4 and 5, respectively. There was no fatality recorded in the acute toxicity tests when the animals received 900-4500 mg kg-1 body weight of the extract, however the higher doses of the extract (2700-4500 mg kg-1 body weight) exhibited some behavioral changes in the rats such as aggressive scratching of the body and mouth part, anorexia, mild restlessness and sensitive to slight sound. There was no significant difference (p< 0.05) in the toxicological parameters investigated when compared with the control. The gastro intestinal tract revealed no apparent congestion or hemorrhage while the histopathological examination of liver and kidney showed no visible lesions indicating its non toxic effect to these organs. These results have provided scientific evidence to justify the safety of this plant in tradition medicine.
 
 
 
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