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Articles by R. Yang
Total Records ( 2 ) for R. Yang
  R. Yang , N. Mohan , C. Muthukumar , N. Thajuddin and M. Gunasekaran
  The influence of cultural conditions that affect GPX production in Candida albicans grown in Lee's medium was investigated. Optimum temperature and pH for GPX activity were 25°C and 7.2, respectively. Substrate specificity for C. albicans. Glutathion peroxidase was in the order of cumene hydroperoxide>t-butyl hydroperoxide> hydrogen peroxide>benzoyl peroxide. Aeration as well as large head space volume enhanced the growth of C. albicans and GPX production. Arabinose and ammonium sulphate significantly increased the GPX synthesis. Among nitrogen sources, polypeptone enhanced both the growth and GPX synthesis. Various cellular activities are regulated by the level of GSH. Therefore, the level of GPX might be used as one of the criteria in developing new drugs against Candida albicans.
  R. Yang , T. Xia , G. Xu , Z. Li , Z. Ying and X. Xu
  Our study sought to investigate the immune response of cytotoxic T lymphocytes to human cytomegalovirus (HCMV) in kidney transplant recipients with virus reactivation. Nine kidney transplant recipients with serum HCMV immunoglobulin G and HLA-A*0201 genotype displayed HCMV pp65 antigenemia and were compared with 29 control recipients who were free of antigenemia. The frequency of total HCMV-specific cytotoxic T cells was determined using HLA-A2-NLVPMVATV-pentamer staining. The frequency of HCMV specific interferon (INF)-γ secreting CD8+ T cells was determined using intracellular INF-γ staining after NLVPMVATV pulsing in vitro. The proportion of IFN-γ secreting pentamer-stained CD8+ T cells was calculated, representing the capacity for INF-γ secretion among HCMV-specific CD8+ T cells. We observed that the frequency of HCMV-specific pentamer-stained CD8+ T cells and HCMV-specific IFN-γ secreting CD8+ T cells both remained unchanged, yet the proportion of IFN-γ secreting CD8+ T cells showed a significant difference between the 2 groups (39.2% ± 17.2% vs 20.0% ± 13.3% respectively; P = .004), reflecting impaired IFN-γ secreting capacity of HCMV-specific CD8+ T cells among kidney transplant recipients displaying antigenemia, which may be a crucial reason for HCMV reactivation in immunosuppressed patients.
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