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Articles by R. Vijayakumar
Total Records ( 5 ) for R. Vijayakumar
  R. Murugeswari , V. Balakrishnan and R. Vijayakumar
  Degradability studies of processed tapioca leaves in the form of hay and silage for both the varieties (White Rose (H226) and Mulluvaadi (MVD-1)) conducted in RUSITEC and compared with unprocessed tapioca leaves. It was found that unprocessed tapioca leaves had high soluble degradable dry matter and high effective degradability than processed (hay and silage) tapioca leaves. The RDN and UDN values were found to vary between unprocessed and processed leaves but the total absorbable nitrogen values were similar between processed and unprocessed for both the varieties. A study was also undertaken to examine the need for supplementation for improvement of microbial production. Supplementation of digestible organic matter to the extent of 10.99 to 12.31% was suggested as a tool to exploit the full potential nutritive value of processed and unprocessed tapioca leaves. Further in vitro rumen fermentation studies also revealed Higher pH (7.30), lower propionic acid (8.05 mM L-1) and TVFA (36.90 mM L-1), higher ammonia nitrogen (12.17 mg%) and lower microbial protein synthesis (45.17 mg%) clearly tilt the favour against unprocessed tapioca leaves and suggestive that processing of tapioca leaves (White Rose (H226) and Mulluvaadi (MVD-1)) was desirable over unprocessed tapioca leaves. Hence this study recommends processing of tapioca leaves as hay or silage for year round availability.
  K.C. Shivanandappa , S. Jagannathan , S. Lokesh , R. Vijayakumar and K.R. Mani
  Studies have been undertaken to investigate, the effect of impeller number and its position upon the growth yield of Bordetella pertussis strain 509 during large scale batch cultivation. It was shown that, the maximum growth yield opacity was found to be 70 IOU mL–1 at 48 h cultivation in single impeller fixed at the bottom position of fermentor vessel. Whereas the optimal and moderate culture opacity 60 and 50 IOU mL–1 was observed during the two impellers mounted at two different positions on the shaft. Similarly the least growth yield was obtained during three impeller located at top, middle and bottom region of the shaft and the final opacity was found to be 30 IOU mL–1 at the end of 48 h cultivation with an increasing of culture pH 8.02. However, in two impeller combination experimental study also showed moderate growth yield at 48 h could give to homogenized mixing and good aeration. Thus, the two different location of the impeller combination influences two vortex flows, enhances optimal growth rate, viz; the lower impeller act as gas disperser and creates radial velocity with higher rates of air dispersion, whereas the upper impeller pumps the broth towards down thus the combined agitation of the broth leads to good mixing and even transfer of Dissolved Oxygen (DO2) to the growing cells and found moderate bacterial growth. In the combination of three impellers mounted at three different positions experimental study shown that, lesser growth yield at the end of 48 h cultivation, due to higher forth accumulation.
  S. Jagannathan , P. Rahul Gandhi and R. Vijayakumar
  Rabies is an acute disease of vertebrate animals which may affect all animals from amphibian to man and it is a single stranded negative sense RNA virus belonging to the genus Lyssavirus of the family Rhabdoviridae. The production of vaccines, diagnosis and further research will therefore continue in this field because a cure for rabies would be a big boon for the developing countries. Virus inactivation is essential for the preparation of vaccines, diagnostic reagent and research purposes. The beta propiolactone (βPL) is widely used as an inactivatent; βPL is very considerable value in the production of biological for virus inactivation and perhaps for DNA inactivation. The inactivation results indicate that the rate of inactivation is directly proportional to the concentration of βPL used. Assessment of the residual βPL present in the vaccine is a mandatory test to vaccine. Vaccine manufacturing also assess the efficacy of inactivation procedure by various in process quality control tests such as tissue culture virus amplification test and inactivation kinetics. This experiments are based on the changing the parameters as well as the various concentration of βPL in the clarified, concentrated high titer of PV11 rabies strain, subsequently that are further purified and formulated with suitable additives and stabilizers. The immunogenicity of the vaccines is analyzed. During the βPL inactivation kinetics gives an idea of the predictable time of inactivation and also the order of inactivation, validation of the inactivation process is an essential part of quality assurance. In the immunobiological industry the time is a crucial factor because to get more inactivated viral harvest yield in a short period and they are processed to further purification and downstream processing. This findings is to reduce the time frame and the residual βPL in various level influenced the tissue culture derived anti rabies vaccine.
  V. Kowsalya , R. Vijayakumar , R. Chidambaram , R. Srikumar , E. Prabhakar Reddy , S. Latha , I. Gayathri Fathima and C. Kishor Kumar
  Knowledge, attitude and practice studies have been used to understand the various factors that influence blood donation which is the basis for donor mobilization and retention strategies. Role of youngsters in voluntary blood donation is crucial to meet the demand of safe blood. The present study was aimed to assess the level of knowledge, attitude and practice regarding voluntary blood donation among the health care students. A validated and pre-tested questionnaire on knowledge, attitude and practice on blood donation were assessed among 371 medical students from Sri Lakshmi Narayana Institute of Medical Sciences and Research Institute, Puducherry, India. Result showed that knowledge on blood donation among respondents was 44.8% (1st year 36.7%, 2nd year 42.8% and 3rd year 54.9%). About 62.6% of non-donors (1st year 51%, 2nd year 61% and 3rd year 77%) showed positive attitude by expressing their willingness to donate blood while 22.8%.of the non-donors had negative attitude (1st year 33%, 2nd year 23% and 3rd year 13%). In practice 13.2% of students had donated blood (1st year 10%, 2nd year 13% and 3rd year 24%), in which 2.7% of male students alone donating blood on regular basis. Over all 3rd year student showed significantly higher knowledge compared with 1st years, in attitude and practice section 3rd year student’s showed significantly higher positive attitude and practice than that of 1st and 2nd years. The present study reveals that there is a positive association among knowledge, attitude and practice on blood donation, which suggest that positive attitude and practice can be improved by inculcating knowledge on blood donation among college students to recruit and donate blood regularly, which will help to achieve 100% of blood donation on voluntary basis.
  V. Kowsalya , R. Vijayakumar , G. Valli , K.P. Bharath , R. Srikumar , C. Kishor Kumar , I. Gayathri Fathima and N. Vanajashi
  Birth weight is an important determinant of child survival, healthy growth and development. Low birth weight is a well-established risk factor for adverse long term health, particularly cardiovascular disease and metabolic syndrome. The ability of the fetus to grow and thrive in utero is presumed to be a function of the placenta. The present study was aimed to assess the morphometry examination of placenta in normal and low birth weight babies in the Union territory of Puducherry. Morphometry examination includes Placenta weight, number of cotyledons, maternal and fetal surface area and site of umbilical cord insertion were measured in normal and low birth weigh babies. Result showed among 200 subjects, mean birth weight of normal and low birth babies were 2806 and 2058 g, respectively. The prevalence rate of low birth babies (less than 2500 g) was 22%. The placental morphometry study namely placental weight, number of cotyledons, maternal and fetal surface area and insertion of umbilical cord at centre were significantly (p<0.001) reduced in the low birth weight babies when compared with normal birth weight babies. Study revealed that morphometry analysis of placenta significantly influences the birth weight of new born. In conclusion, study recommends the early measurements of placenta by non-invasive techniques like ultrasonography will be helpful in early prediction of low birth weight fetus in utero itself and for better management to avoid such low birth weight.
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