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Articles by R. Vasudevan
Total Records ( 7 ) for R. Vasudevan
  V. Anmireddy , R. Vasudevan , D. Anand , T.V. Rao , B.V.N. Kapardhi , D. Trivedi and R.K. Manchanda
  Highly sophisticated balloon-borne scientific payloads have stringent requirement on the telemetry and command system. The development and fabrication of the on-board TT&C package for telemetry, tracking, command, safety and ranging for these experiments is done in-house at the National Balloon Facility (NBF) at Hyderabad. In the last few years, we have made major improvements both in the ground station and the on-board sub-systems, thereby improving the data quality, data handling speed and the general flight control along with aviation safety. The new system has telemetry data rate up to 1 Mbps. A reduction in weight, power and cost of the reengineered on-board integrated package has also lead to the ease of operation during field tests prior to launch and at remote recovery sites. In this paper, we describe the details of the new control package, its flight performance and our plans for portable S-band telemetry and telecommand system to cater to the balloon flights from Antarctic station and long duration balloon flights.
  Ruzainah Ali Jaafar , Ahmad Ridhwan Bin Abdul Rahman , Nor Zaini Che Mahmod and R. Vasudevan

Problem statement: Dragon fruit (Hylecereus polyhizus) is well known for the rich nutrient contents and it is commercially available worldwide for improving many health problems. Several studies show the proximity value of red pitaya fruits but the nutrient composition of the stem has not been extensively studied.
Approach: This study was carried out to measure the proximate analysis of moisture content, water activity, ash, crude protein, crude fat, crude fiber, glucose and ascorbic acids content in premature and mature of dragon fruit. The dried powder was produced from the stem of dragon fruit and the proximate analysis of dragon fruit stem was compared between freeze drying process and drying oven process.
Results of this study showed that 96% moisture; 0.270 g of protein; 0.552 g L-1 glucose and 132.95 mg L-1 ascorbic acid of dragon fruit stem found higher than the fruit flesh of the dragon fruit.
The premature stem had higher values than the mature stem of the dragon fruit which may helpful in preventing the risk factors of certain diseases.

  B. Sahar Ansari , R. Vasudevan , M. Mirinargesi , I. Patimah , A.R. Sabariah , P. Pasalar and Ali Bakhshi
  Problem statement: Glutathione S-transferase is super family genes that encode enzymes which involve in the detoxification of the cell and protects DNA from damage. Conflicting results was found in several studies in association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer. In this study, we determined the association between the GSTT1 and GSTM1 gene polymorphism and prostate cancer in Iranian subjects as control with control subjects. Approach: Sixty number of sample were collected from both case and control at Milad hospital, Tehran, Iran who were above 40 years of old. Genomic DNA was extracted from blood and the detection of GSTT1 and GSTM1 genotypes was done using multiplex PCR method. Results: The frequency of the null alleles in GSTT1 and GSTM1 was 15 and 41.66% respectively in prostate cancer patients and 21.66 and 56.66% respectively in control subjects. There was no association was found between the polymorphism and prostate cancer among Iranian subjects (p>0.05). Conclusion: This study failed to show an association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer and has no susceptibility to Iranian prostate cancer subjects.
  R. Vasudevan , P. Ismail , J. Stanslas and N. Shamsudin
  The objective of this study was to determine the association of Angiotensin-Converting Enzyme (ACE) G2350A polymorphism in Essential Hypertension (EHT) and Type 2 Diabetes Mellitus (T2DM) in Malaysian subjects. A total of 265 samples have been recruited for this study. In order to amplify the 122 bp of G2350A variant of ACE gene, genomic DNA was amplified using Hot-start Polymerase Chain Reaction (PCR) and the PCR products was digested with BstuI restriction enzyme to produce 103 and 19 bp when A is at position 2350. The subjects were ranged from 30 to 84 years old with a mean age of 51.84 years. The frequency for GG, GA and AA genotypes of ACE gene was 41.43, 48.57 and 10% in EHT, 46.67, 36.67 and 16.66% in T2DM, 32.31, 53.85 and 13.84% in T2DM with EHT compared to 61.43, 35.71 and 2.86% of control subjects respectively. The frequency for A allele of G2350A polymorphism was 34.29% in EHT, 35.00% in T2DM, 40.77% in T2DM+EHT subjects compared to controls (20.71%). The genotype and allele frequency of ACE G2350A gene polymorphism differed significantly in patients when compared to controls (p<0.05). Allele A of G2350A polymorphism of ACE gene is associated with essential hypertension and Type 2 Diabetes Mellitus in Malaysian subjects.
  R. Vasudevan , Patimah Ismail , Johnson Stanslas and Norashikin Shamsudin
  The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM, 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.
  R. Vasudevan , Patimah Ismail , Aisyah Ali and Mimi Soraya Mansor
  Several genome-wide association studies were done extensively in many populations in finding the candidate genes predisposing to Type 2 Diabetes Mellitus (T2DM). In that way, Transcription Factor 7-Like 2 (TCF7L2) and Ectoenzyme Nucleotide Pyrophosphate Phosphodiesterase 1 (ENPP1) genetic variants were found to be associated with increased risk of T2DM in various populations. In this cross-sectional study, rs7903146 (C/T) polymorphism of TCF7L2 gene and K121Q polymorphism of ENPP1 gene was analyzed in T2DM with or without hypertension in Malaysian subjects. A total of 165 samples consisting of 50 T2DM without hypertension, 55 T2DM with hypertension and 60 healthy individuals were recruited for this study. Genomic DNA was amplified to determine the genotypes of rs7903146 (C/T) and K121Q polymorphisms using hot start PCR followed by RFLP method. The mean age for patient and control subjects was 57.26±10.02 and 45.65±10.93 years, respectively. There was no significant differences (p>0.05) found in genotype and allele frequency for both rs7903146 (C/T) and K121Q polymorphism of TCF7L2 and ENPP1 gene, respectively. This preliminary results show that both polymorphisms was not an independent risk factor to T2DM with or without hypertension in Malaysian subjects. However, replication studies in this population with larger sample size was strongly recommended.
  R. Vasudevan , Aisyah B.T. Ali , Mimi Sooraya Mansoor , Nurul Fasihah Zulkifli and Patimah Ismail
  The T344C polymorphism of aldosterone synthase CYP11B2 gene at promoter region was vastly studied in various populations with conflicting results in relation to End-stage Renal Disease (ESRD). In this study, researchers aimed to know the association of T344C polymorphism of CYP11B2 gene in Malaysian ESRD subjects. This study involved 165 Malaysian ESRD subjects and 165 healthy individuals as control subjects. Using commercially available kits, genomic DNA was extracted from the subjects using their buccal cells and the blood. The 152 bp product of CYP11B2 gene polymorphism were amplified by Polymerase Chain Reaction (PCR) and digested with Hae III restriction enzyme using Restriction Fragment Length Polymorphism (RFLP) method. The restricted fragments were separated by metaphor agarose gel electrophoresis and showed 152 bp represent TT allele (wild type), 152 and 97 bp represent the TC allele (heterozygous) and 97 and 56 bp represent CC allele (mutant type) as the genotypes for T344C polymorphism. The frequency of TT, TC and CC genotypes of T344C in CYP11B2 gene in ESRD subjects were 98 (59.39), 60 (36.36%) and 7 (4.24%) while 92 (55.76), 70 (42.42) and 3 (1.82%) were found in control subjects, respectively. The genotypic and allelic frequencies of T344C polymorphism of CYP11B2 gene show no significant differences as compared to control subjects (p>0.05). The T allele of T344C polymorphism of CYP11B2 gene might not be considered as a possible genetic marker or predisposing risk factor for ESRD in Malaysian subjects. However, this study has to be further continued with more subjects to confirm the association of CYP11B2 gene mutation with ESRD.
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