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Articles by R. Sundaraganapathy
Total Records ( 1 ) for R. Sundaraganapathy
  S. Kameshwaran , C. Jothimanivannan , R. Senthilkumar , S. Thenmozhi , R. Sundaraganapathy and M. Dhanalakshmi
  Objective: Diarrhea is one of the widespread wellbeing situation upsetting people in less developed countries. This study was done to appraise anti-diarrheal influence of the ethanolic flower extract of Tecoma stans (EETS) using Wistar albino rats to determine the acute toxicity in mice. Material and Methods: The flowers were collected and extracted with 70% ethanol. The dry extract was reconstituted using normal saline for the oral administration to diverse groups of rats at doses of 200, 400 and 600 mg kg-1. Anti-diarrheal activity was resulted using the percentage fall in the incidence of defecation in rats with castor oil-induced diarrhea. Loperamide (1 mg kg-1) was worn as positive control. Acute toxicity was evaluated by fortitude of LD50 and observations of toxic signs. Results: EETS showed momentous (p<0.05) antidiarrheal activity evidenced by the lessening in rate of defecation by up to 78.33% at 600 mg kg-1 b.wt. analogous to loperamide (100%). This activity could be accredited to the phytochemicals such as flavonoids and tannins in Tecoma stans that were present in high levels and have been reported to demonstrate antidiarrheal activity through denaturing protein hence forming protein tannates which curtail the intestinal mucosa permeability. The LD50 of the crude EETS was 10,715 mg kg-1. Conclusion: The findings of this study illustrate that the flower of Tecoma stans have a very significant antidiarrheal commotion and are not dangerous to use as indicated by the high LD50 value. This ropes the conventional use of the EETS as herbal therapy for treatment of diarrhea.
 
 
 
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