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Articles by R. Ramazanzadeh
Total Records ( 2 ) for R. Ramazanzadeh
  R. Ramazanzadeh and F. Nasiri
  The aim of this study was to determination the biological activity of some new synthesized pyrrole compounds. The activity against Gram-positive and Gram-negative bacteria of dimethyl 2-hydroxy-1-methyl-3-[2-oxo-2-phenylethylidene]-2-phenyl-1,2-dihydro-3H- pyrrole-4,5-dicarboxylate I was tested in vitro using six reference bacterial strains. e.g., Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Escherichia coli, Enterobacter earogenes and Pseudomonas aeruginosa. Compound I was active against all strains tested by disk diffusion method in ranging from 15 to 27 mm per 70 μg disk. In conclusion, this compound might be used as a basic to modification in order to synthesize new antibacterial agents.
  M. Mansouri and R. Ramazanzadeh
  The aim of this study was to determine the prevalence of Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli and antimicrobial susceptibility pattern of ESBL-producing and non producing strains. We evaluated 158 E. coli strains isolated from various clinical specimens. The double-disk synergy test was performed on the isolates for the detection of ESBL. These genes were confirmed by PCR methods. The prevalence of ESBL-producing E. coli was found as 16.8%. The ESBL-producing isolate rates were 22.2% (6/27) in intensive care units, 22.2% (6/27) in wards and 44.6% (15/27) in outpatients. This study, present the existence of ESBL-producing isolates and high rate of resistance to antibiotics. Clinicians should be familiar with the clinical importance of these enzymes and potential strategies for dealing with them. The results of the study suggest that community acquired control of ESBL-producing E. coli has great importance.
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