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Articles by R. Mandil
Total Records ( 3 ) for R. Mandil
  R. Rathore , A. Rahal , R. Mandil and A. Prakash
  Mimosa pudica is an indigenous antifertility herb. Its use has been advocated against urinary complaints, hypertension, pain relief and menorrhagia but the use has not been scientifically validated till date. Present study was undertaken to delineate the molecular mechanism of tocolytic activity of Hot Methanolic Extract of Mimosa pudica Seeds (HMEMPS) on isolated uterine strips of pregnant buffaloes. Myometrial strips were prepared, mounted in an organ bath containing Ringer Lock’s solution maintained at 37°C and responses recorded using a physiograph in the presence and absence of different antagonists. M. pudica seeds extract produced concentration-dependent inhibitory effect on buffalo myometrium with an EC50 value of 222.4 μg mL-1 perhaps through inhibitory β receptors. Following propranolol (10-6 M) pretreatment, there was an apparent and marked increase in amplitude of spikes of normal spontaneity. An apparent increase in amplitude of spikes upto 1000 μg mL-1 followed by a decrease with further increase in concentration of HMEMPS was also recorded. Verapamil (10-12 M), a Ca+2-channel blocker, apparently could not significantly alter the HMEMPS-induced inhibiton on buffalo myometrium. Calcium channels did not seem to regulate tocolytic effect of Mimosa pudica seeds extract. Further studies are indicated to explore the involvement of Ca2+ and K+ channels, NO and other signaling mechanisms including second messengers.
  R. Rathore , A. Rahal and R. Mandil
  Ethnoveterinary practices hold a promising scientific resource and can have far-reaching implications on economic development and enhancement of veterinary health care system. The present study was undertaken to evaluate the oxytocic/tocolytic activities of Cimicifuga racemosa (C. racemosa) roots extracts on isolated uterine strips of pregnant buffalo. Hot methanolic extraction of authenticated roots of C. racemosa was done using soxhlet extractor. Hot methanolic extract of C. racemosa roots was found to exert a myometrial relaxant effect which was potentiated after inhibition of excitatory muscarinic, alpha and beta adrenergic, H1-histaminergic and 5-HT receptors. Further studies are required on mechanistic aspects of tocolytic effect of C. racemosa particularly to elucidate the involvement of Ca2+ and K+ channels, NO and other signaling mechanisms including second messengers.
  Mahima , A. Rahal , R. Mandil , A.K. Verma and V. Kumar
  Moringa olifera or the horseradish tree, also known as saijhan, sajna, benzolive, drumstick tree, kelor or marango, is a large tree indigenous to the India and neighbouring countries like Bangladesh, Afghanistan and Pakistan. It is known as one of the world’s most useful trees. Its leaves are used in Indian foods fresh as salads, cooked or stored as dried powder for long periods with minimum loss of nutrients. Leaves of Moringa olifera are also used for treatment of inflammatory conditions, paralysis, hypertension, athlete’s foot and tinea. It acts as galactogogue, rubefacient, an antidote, antiscorbutic, stimulant and diuretic. The study was undertaken to evaluate the proximate and elemental analysis of the leaves of Moringa olifera. The proximate analyses viz., crude protein, crude fibre, total ash, nitrogen free extract, cellulose, hemicelluloses and lignin etc were carried out using standard protocol while mineral analysis was done using Atomic Absorption Spectrophotometer (AAS). The proximate analysis of the leaves of Moringa olifera showed that it contained moisture 72.39%, ether extract 2.525%, crude protein 14.125%, crude fibre 23.09%, total ash 9.15%, nitrogen free extract 51.11%, cellulose 11.00%, hemicellulose 10.24% and lignin 2.41%. The mineral analysis of the leaves showed that they contain the following essential minerals; calcium (199.23 ppm), phosphorous (34.81 ppm), iron (111.058 ppm), copper (8.733 ppm), zinc (69.342 ppm) and manganese (72.242 ppm). The study revealed that Moringa olifera leaves to be a potential source of essential nutrients and minerals especially calcium and iron for man as well as animals and could be utilized to improve growth performance and health benefits.
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