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Articles by R. Hosseini
Total Records ( 2 ) for R. Hosseini
  R. Hosseini , A. Mandegary , K. Alimoghaddam , A. Ghavamzadeh and M.H. Ghahremani
  The high complete remission rate with arsenic trioxide (ATO) in relapsed Acute Promyelocytic Leukemia (APL) patients has been led to its use in newly diagnosed patients. Twenty newly diagnosed APL patients between January 2006 and 2007 received 2 h intravenous infusion of 10 mg day-1 arsenic trioxide for induction therapy until achieving complete remission. Plasma arsenic concentration was analyzed by graphite furnace atomic absorption method by dilution of plasma with a suitable matrix modifier. The concentration of arsenic in 24 h urine of patients was measured by using a valid standard addition method and a suitable matrix modifier. The Limits of Detection (LOD) were 1.2 and 1.5 μg L-1 for arsenic in plasma and urine, respectively. Pharmacokinetic parameters of 20 patients were as following: Cmax: 43.6 ±19.5 μg L-1, tmax: 2.15±0.7 h, AUC0-24: 683±317 μg h L-1, AUC0-∞: 2027±958 μg h L-1, t1/2: 41±10 h, kel: 0.02±0.01 h-1, Vd: 5.6±3.6 L kg-1 and Cltotal: 0.1±0.05 L kg-1 h-1. During the first day of induction, 1.4±0.2% of administrated arsenic excreted into urine. Renal clearance was 5.1±4.1 mL kg-1 h-1. However, the results showed that the pharmacokinetic of ATO in newly diagnosed APL patients weren`t dependent to the sex of patients.
  R. Hosseini and M. Parsa
  Abstarct: Aloe vera L. is a medicinal plant grown in different parts of the world. Several papers have reported the micropropagation of this plant and its response to different combinations of hormones. In this research, we used A. vera plants grown in south Iran. MS culture medium with twenty three combinations of hormones were used, including some of those employed previously by other researchers. Ten media showed positive results and the best result was obtained using Kin (1 mg L-1)+IAA (0.1 mg L-1) which has not been reported before. Produced plantlets rooted in free hormone MS medium and transferred into soil. The survival rate was 83%.
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