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Articles by R. Balaraman
Total Records ( 4 ) for R. Balaraman
  A. Upaganlawar and R. Balaraman
  Present study was carried to evaluate the protective effect of Lagenaria siceraria fruit juice (LSFJ) in isoproteranol (ISO) induced myocardial infarction in rats. Rats treated with ISO (200 mg kg-1, s.c.) for two consecutive days at an interval of 24 h resulted in a significant (p<0.001) alteration in cardiac marker enzymes (alkaline phosphatase, Lactate dehydrogenase, creatine kinase-MB, serum Aspartate Transaminase and alanine Transaminase), lipid peroxidation and endogenous antioxidants activities (reduced glutathione, glutathione peroxidase, glutathione s-transferase, superoxide dismutase and catalase). It also showed alteration in electrocardiographic and hemodynamic parameters. Treatment with LSFJ (400 mg/kg/day, p.o.) for 30 days and challenged with ISO on 29th and 30th day showed a protective effect on serum marker enzymes, LPO, endogenous antioxidants activity, electrocardiographic and hemodynamic changes. These finding indicates, protective effect of LSFJ during isoproterenol induced myocardial infarction and associated oxidative stress in rats.
  Aman Upaganlawar , Hardik Gandhi and R. Balaraman
  Cardiovascular Diseases (CVD) remain one of the leading causes of deaths despite several advancements in the medical interventions. Among these, the ischemic heart diseases, acute myocardial infarction (AMI) in particular, is one of the most alarming values. AMI, which arises out of a lot risk-factors working in concert, gives rise to a lot of unfavorable biochemical outcomes. The end-result of which is the ultimate morbidity of the patient or even death. The synthetic drugs that constitute the current pharmacological armamentarium are themselves effective in managing the condition but not without setbacks. These hunches have accelerated the need for natural products, which may be used as dietary supplement to prevent the development of an acute myocardial infarction. The isoproterenol-induced myocardial infarction in rodents offers a relevant model to study the effect of natural products. The model is simple in execution and the biochemical, histological and electrocardiographic changes closely mimic that seen in case of an AMI. The model has so far been widely used by many researchers to study the effect of drugs in AMI. Natural products, which include crude herbals, extracts, herbomineral formulations, polyherbal formulations, etc., have been used for the treatment of ischemic heart diseases in traditional systems of medicine. A range of natural products have been tried for activity against acute myocardial infarction with considerable success. The colossal collections of chemicals present in the natural products possess antioxidant, anti-inflammatory and other properties that prove useful in ameliorating the pathophysiology of acute myocardial infarction. Besides, these natural products may also augment the conventional treatment and offer better management of the condition with fewer side effects.
  Aman B. Upaganlawar and R. Balaraman
  Background: Consumption of dietary constituents containing polyphenols, flavonoids and vitamins are associated with reduced risk of cardiovascular disorders. In the present myocardial infarction was induced in male albino rats by subcutaneous injection of isoproterenol (ISO) (200 mg kg-1) for 2 consecutive days at an interval of 24 h. Result: ISO injected rats showed a significant (p<0.001) increase in total cholesterol, triglycerides and free fatty acids levels in both serum and cardiac tissue. However, a rise in the levels of serum phospholipids was observed in ISO-injected rats. Further, ISO injected rats showed a significant decrease in the level of high-density lipoprotein in serum and PLs levels in the heart. The activities of lecithin: cholesterol acyl transferase and lipoprotein lipase was significantly (p<0.01, p<0.001) decreased and cholesterol ester synthetase was significantly (p<0.001) increased. ISO injected rats also showed significant increase in area of infarction. Administration of Vitamin E (100 mg/kg/day, p.o.) alone and in combination with lycopene (10 mg/kg/day, p.o.) for 30 consecutive days significantly attenuated these alterations and restored the levels of serum and heart lipids, lipid metabolizing enzymes along with area of infarction. Conclusion: These findings indicate that addition of lycopene along with vitamin E showed better effects rather than vitamin E.
  Aman Upaganlawar and R. Balaraman
  Background: The present study was planned to assess the cardioprotective effects of Pomegranate fruit extract alone and along with vitamin E by evaluating electrocardiographic changes and biochemical changes in isoproterenol (ISO) induced myocardial infarction in rats. Materials and Methods: Myocardial infarction was induced by subcutaneous injection of isoproterenol (200 mg kg-1) for two consecutive days at an interval of 24 h. Rats were treated with pomegranate (100 mg kg-1 day-1, p.o.) and vitamin E (50 mg kg-1 day-1, p.o.) for a period of 30 days and isoproterenol was injected on 29th and 30th day. On day 31st electrocardiographic changes and biochemical changes were monitored from all the experimental groups. Results: Isoproterenol injected rats showed a significant alteration in ECG pattern. It also showed significant increase in C-reactive protein, myeloperoxidase levels, lipid peroxidation and Caspase-3 protease activity. In addition, it also exhibited alteration in the levels of electrolytes (Na+, K+ and Ca++). Significant alteration of ATPases was also observed. Treatment with Pomegranate fruit extract alone and along with vitamin E significantly prevented the isoproterenol induced alteration in electrographic changes and other biochemical alterations. Conclusion: The present result showed that treatment of pomegranate fruit extract alone and along with vitamin E in ISO injected rats significantly attenuates myocardial infarction.
 
 
 
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