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Articles by R. Avizeh
Total Records ( 2 ) for R. Avizeh
  B. Mosallanejad , R. Avizeh and H. Najafzadeh Varzi
  The aim of this study was to detect of the protective action of silymarin on stanozolol-induced-hepatotoxicity in a bitch. A female dog with age 2.5 years-old, Doberman pinscher breed and weighing 24.15 kg was presented to Veterinary Hospital of Shahid Chamran University, in August 2010, with a history of depression, salivation, vomiting and seizures. Conjunctival hyperemia and dilated retinal vessels were main clinical signs. Stanozolol had been administered 24 h ago with high dose (2.5 times maximum dose) by owner. Blood sample was collected from the cephalic vein. Serum enzyme concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total and direct bilirubin, Blood Urea Nitrogen (BUN) and creatinine levels were measured immediately after referring, as indices of liver and kidney injuries. Administration of stanozolol was caused elevatation of serum enzyme concentrations of ALT, AST, ALP, LDH, total and direct bilirubin in the affected dog. Silymarin (Sigma-Aldrich Co., St Louis, MO, USA) at a single dose of 30 mg/kg with other supportive treatments (fluid therapy and vitamin B. complex) were administered immediately. Application of silymarin improved clinical status and serum value enzyme activity was within normal, 24 h after treatment. Oral silymarin could prevent hepatotoxicity due to stanozolol in a dog.
  M. Sayari , R. Avizeh and F. Barati
  Visceral Leishmania (VL) with diverse clinical manifestation is prevalent and remains a major public health problem in Iran. This study was performed in Ahwaz, Khozestan province southwest to increase immune system and to reduce of the renal lesions. Treatment of dogs with visceral leishmaniosis is basically the same as the treatment of human. However, cure is not usually achieved, leaving the sacrifice of animal as the only feasible choice. The goal of this work was to test the therapeutic efficacy of N-methyl glutamic antimoate (glucnime), Mycobacterium vaccae adjuvant (SRL 172), alone and in association with L. major promastigote and the latter compound in association to glucantime, in dog with visceral leishmaniasis. In this trial 18, mixed bred dogs with different ages, receiving amastigte promastigote of L. infantum intravenously were used. They were monitored for 6 months. Serologic assays (Elisa, Dot and IFAT) were perfomed on blood samples of each animal. The animals were divided into six groups, each having 3 dogs: Group 1: receiving 100 mg kg-1 day-1 Glucantime for 30 days, IM. Group 2: Receiving 3 mg dog-1 (0.1 mL) of Mycobacterium vaccae adjuvant suspension intradermaly. Group 3: receiving L. major promastigote plus M. vaccae adjuvant each of them 0.1 mL intradermaly by one month intervals for 3 months. Group 4: receiving Glucantime in association L. major promastigote plus M. vaccae adjuvant with previous doses. Group 5: Receiving no treatment. Group 6: was control group with no infection and treatment. In microscopic evaluation following lesions have been shown in kidney: Chronic, interstitial nephritis, sever glomerulosclerosis, membranoproliferative glomerulonephritis and also non suppurative nephritis were the lesions in 5 groups. The prescription of Mycobacterium vaccae adjurant was able to reduce the number of parasites in the macrophages of liver and spleen in this round of treatment.
 
 
 
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