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Articles by R. Asmah
Total Records ( 3 ) for R. Asmah
  N.A. Norfarizan-Hanoon , R. Asmah , M.Y. Rokiah , O. Fauziah and H. Faridah
  The aim of the present study was to investigate the effect of Strobilanthes crispus juice on glucose, lipid profile, glutathione peroxidase and superoxide dismutase in normal and streptozotocin-induced diabetic male and female albino Sprague-Dawley rats. This study was conducted on normal and streptozotocin-induced diabetic male and female Sprague-Dawley rats fed with basal diet and S. crispus juice with different doses 1.0, 1.5 and 2.0 mL k-1 b.wt. for 30 days. The results showed that significant (p<0.05) decrease in serum glucose levels in male and female diabetic and normal rats with treated S. crispus juice (1.0, 1.5 and 2.0 mL k-1 b.wt.). Cholesterol and triglyceride level significantly (p<0.05) decreased in diabetic rats treated with 1.0, 1.5 and 2.0 mL k-1 b.wt. of S. crispus juice. Cholesterol, triglyceride and LDL-cholesterol level showed reduction in treated male and female normal rats. HDL-cholesterol showed the increasing but not significant (p<0.05) difference in treated diabetic and normal male and female rats. Glutathione peroxidase and superoxide dismutase activities significantly (p<0.05) increased in treated diabetic and normal male and female rats. In conclusion, S. crispus juice possesses antihyperglycemic, hypolipidemic and antioxidant effect in streptozotocin-induced diabetic rats. Thus, S. crispus juice could be the alternative treatment for lowering glucose, cholesterol and triglyceride for diabetic patients in the future.
  N.A. Norfarizan-Hanoon , R. Asmah , M.Y. Rokiah , O. Fauziah and H. Faridah
  The objective of this study is to determine the effect of Strobilanthes crispus Juice (SCJ) on wound healing and antioxidative enzymes activity in normal and streptozotocin-induced rats. A total of 48 male albino Sprague dawley rats, weight 150-200 g were used. The rats were divided into 8 groups with 6 rats in each group. The healing of 2 cm linear incisions created on the back of each rat was monitored by measuring the length of the wounds daily. The result showed a significant increase (p<0.05) in the percentage of wound healing at day 3 and 7 in the treated group especially treated with 140 mg kg-1 b.wt. of S. crispus juice in diabetic and normal rats compared with the control. Strobilanthes crispus juice increased significantly (p<0.05) of glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in treated group in diabetic rats. Significant correlation was found between wound healing, GPx and SOD enzymes. In conclusion, S. crispus juice enhanced wound healing in normal and diabetic rats.
  O. Fauziah , P. Hanachi , S. Yogespiriya and R. Asmah
  The effect of 5% w/v of Strobilanthes crispus (SC) extract and glycyrrhizin in diethylnitrosamine and acetylaminofluorene induced hepatocellular carcinoma, which is a vital mechanism in cancer treatment, was studied in male Sprague-Dawley rats. The obtained results have shown a significant, increase (p<0.05) of liver microsome Aniline Hydroxylase (AH) in cancer group rats after 12 weeks. Treatment with glycyrrhizin caused decrease in liver AH activity compared to control. Meanwhile, treatment with SC caused overall decrease in liver AH activity almost near to control groups. Meanwhile, microscopic observation of the lesion score during hepatocarcinogenesis revealed that cells of cancer group without treatment were severely necrotic at week 12. However, S. crispus treatment was reduced the severity in cancer group rats at week 12. The result also indicate that SC only ameliorated the cancer incidence in the liver, however did not fully recover the liver tumor similar to the normal cells. This might be due to short experimental duration.
 
 
 
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