Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by R. Arora
Total Records ( 6 ) for R. Arora
  G ASHRITH and R. ARORA
 

An obese woman with long-standing uncontrolled type 2 diabetes mellitus presents with indurated thickening of the skin on her back. What is the diagnosis?

  N.S. Gill , A. Sharma , R. Arora and Dr. M. Bali
  The present investigation was carried out to evaluate the antioxidant potential using various in vitro methods by 1, 1-diphenyl-2-picrylhydrazyl and Hydrogen peroxide. Antiulcerogenic effect of methanolic Cassia tora seed extract was evaluated by pyloric ligation and non-steroidal anti inflammatory induced mucosal damage on Wistar Albino rats. The phytochemical screening shows the presence of various phytoconstituents belonging to class of alkaloids, flavonoids, triterpenoids and steroids. The extract showed maximum antioxidant activity i.e., 76.35±0.52 and 70.17±0.14 by 1, 1-diphenyl-2-picrylhydrazyl and Hydrogen peroxide at the dose of 200 μg mL-1, respectively as compared to the standard (ascorbic acid). Further, antiulcer activity was assessed in which the experimental animals were divided into five groups categorized as control, standard, normal and two extract treated groups. Various biochemical parameters such as gastric volume, free and total acidity was recorded from all groups. The reduction of ulcer index as well as gastric acid output in extract treated animals was found to be statistically significant with respect to control animals. The extract exhibited optimum percentage inhibition of 75% by pyloric ligation and 70.31% by non-steroidal anti inflammatory induced ulcer method at concentration of 200 μg mL-1, respectively which was comparable to standard (ranitidine). Cassia tora Linn. is well known traditional plant used in Chinese and Ayurvedic medicine. The present study suggests that Cassia tora seed extract possessed potent anti-ulcerogenic properties that might be afforded via cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of Cassia tora seeds in the treatment of antiulcer.
  N.S. Gill , S. Singh , R. Arora and M. Bali
  During the past few decades, the drugs from natural products have gained importance in the field of medicine. Many plants and their products exhibit marked pharmacological activities. Lagenaria siceraria fruit is one of the important natural plant which is used in the treatment of various disorders. The present study was designed to investigate the antioxidant, anti-inflammatory and analgesic potential of ethanolic extract of Lagenaria siceraria seeds. The Lagenaria siceraria seeds were evaluated for their antioxidant potential by 1,1-diphenyl-2-picrylhydrazyl method. The extract showed significant antioxidant potential in a dose dependent manner as compared to ascorbic acid. The extract showed maximum scavenging activity i.e., 75.19% at 200 μg by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging method. Thus, it was further studied for anti-inflammatory activity by Carrageenan induced rat paw edema and analgesic activity by Tail immersion method and Hot plate method at different concentrations i.e., 100, 200 and 300 mg kg-1. The results showed that ethanolic extract of Lagenaria siceraria seeds possess good therapeutic potential and may be useful as a natural antioxidant and it can be used in the treatment of inflammation and pain.
  T. Sharma , R. Arora and N.S. Gill
  The different parts of Luffa echinata “Bindaal” plant are traditionally claimed and scientifically proved to be used in Liver disorders, jaundice, poisoning and migraine as antioxidant etc. but seeds part of this plant has not been explored yet. The present study was designed to investigate the free radical scavenging, anti-inflammatory and analgesic potential of methanolic extract of Luffa echinata seeds (MELE). Free radical scavenging potential of MELE was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl method). The extract showed significant (p<0.05) free radical scavenging activity in dose dependent manner as compared with Ascorbic acid. The maximum free radical scavenging activity of MELE was found to be 82.34% at concentration of 150 μg mL-1 by the DPPH free radical scavenging method. Antioxidant effect was also investigated qualitatively using 1,1-diphenyl-2-picrylhydrazyl. The extract was further evaluated for its anti-inflammatory activity by using carrageenan-induced paw oedema in rats. Analgesic activity was evaluated by tail immersion and Hot plate methods in mice. Anti -inflammatory and analgesic activities were evaluated at dose level 50, 150 and 200 mg kg-1. The extract showed significant decrease in paw volume (60.57% reduction) and analgesic effect shown at the dose level of 200 mg kg-1 as compared to the reference drug diclofenac sodium. The MELE may be useful as a natural antioxidant in the treatment of inflammation and pain.
  N.S. Gill , R. Sharma , R. Arora and M. Bali
  The present study was carried out to evaluate the antioxidant and antibacterial activity of methanolic leaf extract of Hippophae rhamnoides L. (Sea buckthorn, SBT) leaves under in vitro conditions. The chemical composition of the methanolic leaf extract was quantified in terms of total phenol and flavonoid contents. The Hippophae rhamnoides methanolic leaf extract exhibited potent antioxidant activity determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and then by 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), assays. The scavenging capacity by DPPH and ABTS of the extracts was found to increase with every unit increase of Hippophae rhamnoides leaf extracts reaching 68% at 30 μg mL-1 concentration. Further, the extract was evaluated for antibacterial activity against three human pathogenic bacteria E. coli, A. protophormial and M. luteus, however, it was maximum against E. coli. The study shows that the methanolic extract of Hippophae rhamnoides leaves have marked antioxidant and antibacterial activities.
  N.S. Gill , S. Dhawan , A. Jain , R. Arora and M. Bali
  These seeds have been traditionally used for various diseases like dysentery, diarrhoea, piles, keeping in mind of their traditional value our present study was to explore wild Punica granatum seeds for its antioxidant and antiulcer potential. The phytochemical screening of the ethanolic seed extract indicates the presence of triterpenoid, sterols, alkaloids, flavonoids, tannins and coumarin glycoside. Antioxidant activity of the wild Punica granatum ethanolic seed extract was measured by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide free radical scavenging method. Further it was evaluated for its anti-ulcer activity by pyloric ligation model in wistar albino rats. Gastric volume, ulcerative index and free and total acidity were measured in this model. The extract showed maximum scavenging activity i.e., 82.80±0.267 and 74.91±0.235 at 100 μg mL-1 by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide method respectively as compared to the standard (ascorbic acid) in case of quantitative analysis and showed yellow coloration with 1,1-diphenyl-2-picrylhydrazyl scavenging radical in case of qualitative analysis. In pyloric ligation method, the extract showed optimum percentage inhibition of 74.51% at 100 μg mL-1 which was comparable to the standard (ranitidine). The present study concludes that wild Punica granatum ethanolic seed extract possesses significant antioxidant and anti-ulcer activities.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility