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Articles by R. Manoj Kumar
Total Records ( 3 ) for R. Manoj Kumar
  R. Manoj Kumar , R. Anbazhagan , C.C. Satheesh , V. Balamurugan , V. Mrudula and K. Porteen
  The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival and transmission. Vertebrates have developed immunity and at the same time the invading viruses have discovered elegant ways to circumvent the host`s immune mechanisms. One of the defense strategies that counteract the immune responses of the infected host exploits viral immunomodulators that directly interfere with the host`s cytokine system. Virus encoded immunomodulators (Virokines), enables viruses to create favorable habitat, which preserves them by protecting against damage from the inflammatory response, as well as by blocking apoptosis, until the virus replicates to high titers and finds another host. Virokines are clinically and therapeutically beneficial to the medical field and also having potential implications in viral epidemiology, treatment or prevention of viral and inflammatory diseases and for the development of safer vaccines. The endogenous secretion of the virus immunomodulators is thus emerging as an important mechanism of viral control, which is potentially inducible by effective vaccines. The in depth knowledge of the interactions between viruses and the virokines may lead to novel therapeutic and preventive strategies for the control of viral inflammatory diseases. There is no doubt that these virokines will serve as useful starting points for the development of new treatment tools in the new millennium.
  R. Manoj Kumar , A. Sanyal and D. Hemadri
  In the present work, the effect of antibodies (raised in Bovine against IND 63/72 and in Guineapigs against IND 63/72 and IND 491/97) on foot-and-mouth disease serotype Asia1 vaccine strain IND 63/72 was compared by analyzing the data obtained in nucleotide sequencing. The Nr viruses (neutralization resistant viruses) which were selected by growing them in the presence of antibodies (Bovine Vaccinate Serum, BVS and Guineapig Serum, GPS) showed certain characteristic features like common changes in the structural protein coding P1 region of this virus. This shows that the virus responds equally to the antibodies raised in both bovine (natural host) and guineapig (experimental host). The result hereIn extends the finding that selection exerted by host antibody also plays a major role in the rapid evolution of FMD Virus serotype Asia1.
  S. Biswas , A. Sanyal , D. Hemadri , C. Tosh , S. K. Gupta , M. Mittal , J. K. Mohapatra , G. P. Sabarinath , R. Manoj Kumar and S. K. Bandyopadhyay
  Foot-and-Mouth Disease (FMD), the most economically important disease of cloven-hoofed animals is endemic in India. A total of twenty field isolates belonging to serotype Asia1, collected from different states in India during 1986-2002 were taken as BHK-21 cell culture adapted virus from the National Repository of FMDV at the Project Directorate on Foot-and-Mouth Disease (PD FMD). RT-PCR products of the revived viruses were confirmed by agarose gel electrophoresis and the gel-purified products were subjected to cycle sequencing in an automated sequencer. Vpg protein, which on uridylation serves as a primer during FMDV replication is found conserved across serotypes O, A and C. The sequences generated in the present work were compared with respect to other serotypes with the objective of investigating the amino acid variability of the three redundant copies of VPg proteins in a diverse group field isolates of type Asia1.
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