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Articles by R. M Scearce
Total Records ( 1 ) for R. M Scearce
  M. A Moody , H. X Liao , S. M Alam , R. M Scearce , M. K Plonk , D. M Kozink , M. S Drinker , R Zhang , S. M Xia , L. L Sutherland , G. D Tomaras , I. P Giles , J. C Kappes , C Ochsenbauer Jambor , T. G Edmonds , M Soares , G Barbero , D. N Forthal , G Landucci , C Chang , S. W King , A Kavlie , T. N Denny , K. K Hwang , P. P Chen , P. E Thorpe , D. C Montefiori and B. F. Haynes
 

Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly neutralize HIV-1 are rare and are not induced by current vaccines. We report that four human anti-phospholipid monoclonal antibodies (mAbs) (PGN632, P1, IS4, and CL1) inhibit HIV-1 CCR5-tropic (R5) primary isolate infection of peripheral blood mononuclear cells (PBMCs) with 80% inhibitory concentrations of <0.02 to ~10 µg/ml. Anti-phospholipid mAbs inhibited PBMC HIV-1 infection in vitro by mechanisms involving binding to monocytes and triggering the release of MIP-1 and MIP-1β. The release of these β-chemokines explains both the specificity for R5 HIV-1 and the activity of these mAbs in PBMC cultures containing both primary lymphocytes and monocytes.

 
 
 
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