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Articles by R. J Grumont
Total Records ( 1 ) for R. J Grumont
  I Isomura , S Palmer , R. J Grumont , K Bunting , G Hoyne , N Wilkinson , A Banerjee , A Proietto , R Gugasyan , W Li , A McNally , R. J Steptoe , R Thomas , M. F Shannon and S. Gerondakis
 

During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory T (T reg) cells. Although Foxp3 maintains a pattern of gene expression necessary for T reg cell function, other transcription factors are emerging as important determinants of T reg cell development. We show that the NF-B transcription factor c-Rel is highly expressed in thymic T reg cells and that in c-rel–/– mice, thymic T reg cell numbers are markedly reduced as a result of a T cell–intrinsic defect that is manifest during thymocyte development. Although c-Rel is not essential for TGF-β conversion of peripheral CD4+CD25 T cells into CD4+Foxp3+ cells, it is required for optimal homeostatic expansion of peripheral T reg cells. Despite a lower number of peripheral T reg cells in c-rel–/– mice, the residual peripheral c-rel–/– T reg cells express normal levels of Foxp3, display a pattern of cell surface markers and gene expression similar to those of wild-type T reg cells, and effectively suppress effector T cell function in culture and in vivo. Collectively, our results indicate that c-Rel is important for both the thymic development and peripheral homeostatic proliferation of T reg cells.

 
 
 
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