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Articles by R. Hemalatha
Total Records ( 2 ) for R. Hemalatha
  R. Hemalatha , Y. Kodandhapani and N. Balakrishna
  Animal studies have shown that in addition to generalized effects on immune function, zinc and vitamin A can influence Th1 and Th2 cytokine responses and thus have a profound impact on the outcome of infectious illnesses. However, vitamin A supplementation studies on children with respiratory infection are controversial. It is hypothesized that vitamin A may modulate the Th1 and Th2 bias and alter the course of respiratory infection. Therefore in this study, the micronutrient status of children during acute respiratory infection and their association with local cytokine response was determined. In addition, to study the impact of large dose vitamin A on Th1 and Th2 modulation, cytokine response was studied after oral administration of 2 lacs IU of vitamin A in normal children. Seventy two children aged 10 months to 3 years with ARI were recruited from Niloufer Hospital, Hyderabad. Cytokine response, hemoglobin status, serum zinc and vitamin A levels were determined in these children with vitamin A deficiency and compared with thirty apparently normal children of similar age group and socioeconomic status. In ten normal children, cytokine response was studied after oral administration of 2 lakhs IU of vitamin A. Correlation coefficient on log-transformed data showed a significant (p<0.05) inverse association of serum vitamin A and nasopharyngeal aspirate IL2 in children with acute respiratory infection. Other nutritional parameters (weight for age, hemoglobin and zinc) showed no correlation with nasopharyngeal aspirate IL2. Children supplemented with vitamin A showed a significant (p<0.05; paired t test) decrease in IL2 response from peripheral blood mononuclear cell culture supernatant compared to the baseline concentration. The study shows that vitamin A modulates TH1 response, which may be responsible for the increased morbidity seen when children with ARI are supplemented with Vitamin A.
  L. Singotamu , R. Hemalatha , P. Madhusudhanachary and M. Seshacharyulu
  T helper subset response to P. falciparum is well documented, however there is little or no information with respect to P. vivax, though it is associated with high rate of morbidity and hospitalisation. In the present study circulating IL-2, IFNγ, IL12, IL10, IL-4 and TNFα concentrations were investigated in patients with mild and severe P. vivax infection. Hemoglobin status, Packed Cell Volume (PCV), serum zinc and vitamin A were also evaluated. Hemoglobin concentration was low, as expected and further decreased significantly in 1 week of malaria and was negatively correlated with TNFα, suggesting a role for this cytokine in the pathogenesis of anemia and destruction of RBCs. The initial level of TNFα was significantly correlated with IL10 concentration (regression analysis) thus indicating an anti-inflammatory role for IL10 in the regulation of TNFα. Initial concentration of IL2, IL12 and IL10 were higher in the mild malaria and were associated with low parasite density. In contrast, high concentration of IFNγ was associated with low IL2 levels in severe malaria, suggesting that in severe malaria there is an inability to mount a TH1 response (IL-2) and to maintain an adequate balance of Th1/Th2 response. Both serum zinc and vitamin A were low in mild malaria, however, with increasing severity, serum zinc concentrations increased which could be an adaptive response to potentiate the immune response as reflected by the increase in IFNγ and TNFα. Though there was no significant correlation, higher vitamin A levels were associated with low IL-2 levels implicating vitamin A in down regulating Th1 response.
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