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Articles by R. B Hayes
Total Records ( 3 ) for R. B Hayes
  L Dossus , R Kaaks , F Canzian , D Albanes , S. I Berndt , H Boeing , J Buring , S. J Chanock , F Clavel Chapelon , H. S Feigelson , J. M Gaziano , E Giovannucci , C Gonzalez , C. A Haiman , G Hallmans , S. E Hankinson , R. B Hayes , B. E Henderson , R. N Hoover , D. J Hunter , K. T Khaw , L. N Kolonel , P Kraft , J Ma , L Le Marchand , E Lund , P. H.M Peeters , M Stampfer , D. O Stram , G Thomas , M. J Thun , A Tjonneland , D Trichopoulos , R Tumino , E Riboli , J Virtamo , S. J Weinstein , M Yeager , R. G Ziegler and D. G. Cox
 

Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. We conducted a study within the Breast and Prostate Cancer Cohort Consortium to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6292 breast cancer cases and 8135 matched controls and 8008 prostate cancer cases and 8604 matched controls. The large sample sizes and comprehensive single nucleotide polymorphism tagging in this study gave us excellent power to detect modest effects for common variants. After adjustment for multiple testing, none of the associations examined remained statistically significant at P = 0.01. In analyses not adjusted for multiple testing, one IL6 polymorphism (rs6949149) was marginally associated with breast cancer risk (TT versus GG, odds ratios (OR): 1.32; 99% confidence intervals (CI): 1.00–1.74, Ptrend = 0.003) and two were marginally associated with prostate cancer risk (rs6969502-AA versus rs6969502-GG, OR: 0.87, 99% CI: 0.75–1.02; Ptrend = 0.002 and rs7805828-AA versus rs7805828-GG, OR: 1.11, 99% CI: 0.99–1.26; Ptrend = 0.007). An increase in breast cancer risk was observed for the PTGS2 polymorphism rs7550380 (TT versus GG, OR: 1.38, 99% CI: 1.04–1.83). No association was observed between PTGS2 polymorphisms and prostate cancer risk. In conclusion, common genetic variation in these two genes might play at best a limited role in breast and prostate cancers.

  L Mirabello , S. I Berndt , G. F Seratti , L Burdett , M Yeager , S Chowdhury , K Teshome , A Uzoka , C Douglass , R. B Hayes , R. N Hoover , S. A Savage and the National Osteosarcoma Etiology Study Group
 

Osteosarcoma is a primary bone malignancy that typically occurs during the pubertal growth spurt. Only a few small association studies have evaluated common germ line variation in individuals with osteosarcoma. The 8q24 chromosomal region contains several loci that are associated with risk of many different cancers. We conducted an association study of common single-nucleotide polymorphisms (SNPs) across 8q24 to explore the role this region may play in osteosarcoma risk. We genotyped 214 tag SNPs in 99 osteosarcoma cases and 1430 controls (65 controls from a hospital-based case–control study and 1365 controls from a population-based study). Additive, dominant and recessive genetic models were evaluated using unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Analyses of nine SNPs previously associated with cancer did not show strong statistically significant associations. Of the remaining 205 SNPs, 7 were statistically significant (P ≤ 0.05) in one or more genetic models; the most significant association was observed for the additive effect of the minor allele at rs896324 (OR 1.75, 95% CI 1.13–2.69, P = 0.01). This study suggests that several SNPs in 8q24 may be associated with osteosarcoma, but the susceptibility observed was modest. Future large studies of osteosarcoma genetic risk factors are warranted to improve our understanding of the genetic contribution to this cancer of adolescents and young adults.

  C. S Lee , R. B Hayes , E. L McQuaid and B. Borrelli
 

Introduction. Only one previous study on minority retention in smoking cessation treatment has been conducted (Nevid JS, Javier RA, Moulton JL III. Factors predicting participant attrition in a community-based, culturally specific smoking cessation program for Hispanic smokers. Health Psychol 1996; 15: 226–29). We investigated predictors of intervention completion and assessment completion among Latino smokers (n = 131) with asthmatic children participating in a home-based asthma education study that included smoking cessation counseling. Methods. We examined a variety of pretreatment demographic and psychosocial predictors of intervention completion (completing all three home visits versus <3), assessment completion (attendance/not) and total study participation (completing all six contacts versus <6). Results. Lower levels of depressed mood (OR = 0.912, 95% CI: 0.857–0.971, P < 0.01) and fewer ‘pros’ of smoking (OR = 0.882, 95% CI: 0.809–0.961, P < 0.01) predicted intervention completion. Predictors of assessment completion included having more friends who smoke (OR = 2.09, 95% CI: 1.23–3.56, P < 0.01), fewer pros of smoking (OR = 0.87, 95% CI: 0.81–0.95, P < 0.01) and a strong belief that quitting smoking would benefit the child's asthma (OR = 1.69, 95% CI: 1.04–2.74, P < 0.05). Unemployed participants were more likely to complete all six study contacts than those who were working (OR = 0.37, 95% CI: 0.14–0.99, P < 0.05). Discussion. Findings suggest the need to tailor retention strategies during active treatment and follow-up assessments to target those who at risk of dropping out.

 
 
 
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