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Articles by R Watanabe
Total Records ( 3 ) for R Watanabe
  Y Kuwano , K Ishizaki , R Watanabe and H. Nanko

Objective  To determine the efficacy of ultrasonography for the diagnosis of subcutaneous benign lesions.

Design  Retrospective study.

Setting  Tokyo Kousei-Nenkin Hospital, Tokyo, Japan.

Patients  The study included 183 patients with subcutaneous benign lesions who underwent ultrasonography and then received a pathologic diagnosis after surgery.

Main Outcome Measures  The study evaluated the number of cases in which the preoperative diagnosis after ultrasonography or just after palpation agreed with the pathologic diagnosis.

Results  Ultrasonography significantly increased the preoperative diagnostic yield of subcutaneous benign lesions (after palpation, 29%; after ultrasonography, 46%; P < .001). The sensitivity for the diagnosis of lipoma (after palpation, 54.8%; after ultrasonography, 88.1%; P < .01) and the specificity for the diagnosis of epidermal cyst (after palpation, 93.5%; after ultrasonography, 99.3%; P < .05) significantly increased after ultrasonography. The sensitivity for the diagnosis of epidermal cyst and ganglion also tended to increase after ultrasonography.

Conclusion  The study results suggest that ultrasonography is useful for the preoperative examination of subcutaneous benign lesions.

  R Watanabe , M. M Lemos , S. R Manfredi , S. A Draibe and M. E. F. Canziani

Background and objectives: Coronary artery calcification (CAC) is highly prevalent among patients with chronic kidney disease (CKD), and it has been described as a strong predictor of mortality in the dialysis population. Because there is a lack of information regarding cardiovascular calcification and clinical outcomes in the earlier stages of the disease, we aimed to evaluate the impact of CAC on cardiovascular events, hospitalization, and mortality in nondialyzed patients with CKD.

Design, setting, participants, & measurements: This is a prospective study including 117 nondialyzed patients with CKD (age, 57 ± 11.2 years; 61% male; 23% diabetics; creatinine clearance, 36.6 ± 17.8 ml/min per 1.73 m2). CAC was quantified by multislice computed tomography. The occurrence of cardiovascular events, hospitalization, and death was recorded over 24 months.

Results: CAC >10 Agatston units (AU) was observed in 48% of the patients [334 (108 to 858.5) AU; median (interquartiles)], and calcification score ≥400 AU was found in 21% [873 (436–2500) AU]. During the follow-up, the occurrence of 15 cardiovascular events, 19 hospitalizations, and 4 deaths was registered. The presence of CAC >10 AU was associated with shorter hospitalization event-free time and lower survival. CAC ≥400 AU was additionally associated with shorter cardiovascular event-free time. Adjusting for age and diabetes, CAC ≥400 AU was independently associated with the occurrence of hospitalization and cardiovascular events.

Conclusions: Cardiovascular events, hospitalization, and mortality were associated with the presence of CAC in nondialyzed patients with CKD. Severe CAC was a predictor of cardiovascular events and hospitalization in these patients.

  M Tomura , Y. S Mori , R Watanabe , M Tanaka , A Miyawaki and O. Kanagawa

Fluorescent protein that detects caspase-3 activation was used for the time-lapse observation of CTL–target cell interaction. In the target cells transfected with SCAT3.1 (caspase-3-sensitive fusion protein) complementary DNA, caspase-3 activation can be detected significantly earlier than the commonly used annexin-V binding that detects membrane change in apoptotic cells. Moreover, during the cytolytic interaction between OE4 CTL and W3 tumor target cells, detachment of CTL from the target cells occurred prior to caspase-3 activation and death of the target cells, indicating very early sensing of apoptotic target cells by CTL. This early detachment of OE4 CTL from W3 target cells was inhibited by the expression of CD80 co-stimulatory molecule on the target cells. Taken together, time-lapse observation of cellular interaction with functional probe, SCAT3.1 provides new kinetic information and demonstrates that co-stimulatory molecules regulate the kinetics of CTL–target cell interaction.

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