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Articles by R Suriano
Total Records ( 3 ) for R Suriano
  R Suriano , J Edge and D. Bishop
  Purpose

In this study, the effects of variable and constant-intensity cycling on muscle glycogen depletion patterns and subsequent running economy was examined. 60 minutes of cycling at a constant power (CON) or variable intensity (VAR) followed by a treadmill run to determine running economy was completed by nine male triathletes (Vo2max = 67.7 (4.9 ml) kg min–1). During CON, there was greater glycogen depletion in the type I fibres compared with type II (0.08 (0.04) vs 0.02 (0.01) optical density (OD) units; p<0.05), while during VAR, there was greater glycogen depletion in the type II fibres compared with type I (0.06 (0.03) vs 0.03 (0.02) OD; p<0.05). The variation in muscle glycogen depletion patterns was not associated with the detriment in running economy, which was not significantly different between conditions (52.1 vs 52.8 ml kg–1 min–1). There was a strong correlation between total muscle glycogen depletion and the change in running Vo2 (r = 0.73, p<0.05) when the data from both trials were combined. There was also a negative correlation between type I fibre percentage and glycogen depletion within type II fibres during CON (r = –0.85, p<0.05). The results demonstrate that the decrease in running economy, subsequent to 60 minutes of cycling, is not affected by the cycling strategy employed. While different glycogen depletion patterns in the type I and II fibres were observed between conditions, total glycogen depletion may be more important to subsequent running economy. The percentage of type I fibres was associated with the glycogen depletion pattern during constant load, but not variable-intensity exercise.

  R Suriano , S. K Ghosh , A Mittelman , A Banerjee and R. K Tiwari
 

Cancer-derived heat shock protein gp96 induces a tumor-specific protective immune response primarily mediated by cytotoxic T lymphocytes (CTL) directed toward cancer-associated peptides associated with gp96. Both innate and adaptive immune responses have been demonstrated using a cell culture-based signaling mechanism. When used as an extraneous vaccine, one critical interaction which must occur for an immune response to be generated is the interaction between gp96 and the antigen presenting cell (APC) surface receptors (CD91, SR-A, TLR-2, and TLR-4). Our previous study concluded that gp96 purified from various rat and human prostate cancers is differentially glycosylated based on the amino and neutral monosaccharide content, and it was postulated that the monosaccharides may play a role in its biological activity. In this report, we report differences in the cancer-specific sialic acid content of gp96 purified from normal rat prostate compared to two rat prostate cancers, MAT-LyLu and Dunning G, as well as between two human prostate cancer cells, LnCaP and DU145. We also examined the modulatory effect of sialic acid residues on the binding of gp96 to APCs and its subsequent activation. Our results supported the contention that significant differences in the sialic acid content exist between Dunning G, MAT-LyLu, and normal rat prostate gp96, which affected its binding and biochemical activity to APCs. We therefore postulate that varied glycans of HPS96, a hitherto neglected structural component, may play a pivotal role in its anticancer activity. We suggest that construction of the glycan tree is a key to identification of the necessary and sufficient elements in the structure–function activity of HSP96.

 
 
 
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