Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by R Rocchi
Total Records ( 1 ) for R Rocchi
  H. J Kimura , R Rocchi , M. A Landek Salgado , K Suzuki , C. Y Chen , M Kimura , N. R Rose and P. Caturegli

Interferon (IFN)- has been involved in the pathogenesis of Hashimoto thyroiditis. It is a cytokine released by infiltrating mononuclear cells that mediates its actions mainly through signal transducer and activator of transcription-1 (STAT1) but also through other transcription factors. To dissect the effect of IFN on thyroid morphology and function, we crossed transgenic mice that express IFN specifically in the thyroid gland to mice deficient in STAT1. Lack of STAT1 ameliorated the abnormal thyroid morphology and the primary hypothyroidism typical of IFN transgenic mice but not the suppressed iodine accumulation. Interestingly, lack of STAT1 alone decreased iodine accumulation, seemingly through expression of TGFβ. These results indicate that STAT1 is required to mediate some but not all of the phenotypic changes induced by IFN and that it also regulates iodine accumulation via TGFβ signaling.

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility