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Articles by R Rivera
Total Records ( 2 ) for R Rivera
  R. P Olympia , R Rivera , S Heverley , U Anyanwu and M. Gregorits

Objectives. To determine the compliance of a select number of families with national recommendations for disaster preparedness. Patients and Methods. A questionnaire focusing on knowledge of community evacuation plans and the presence of a family emergency response plan was distributed simultaneously in Dauphin County, Pennsylvania, and Bronx County, New York. Results. A total of 1024 questionnaires were analyzed, and it was found that 35% (95% confidence interval [CI] = 32-38) of families were familiar with community evacuation plans, and 43% (95% CI = 40-46) had a family emergency response plan. Also, 17% (95% CI = 15-19) of respondents had discussed preparedness with their primary care physician; this subset of respondents was more likely to be familiar with community evacuation plans and was more likely to have a family emergency response plan. Conclusions. These data show that families are, for the most part, not in compliance with national recommendations for preparedness. Families who discussed preparedness with their primary care physician were more likely to be compliant.

  C. N Jenne , A Enders , R Rivera , S. R Watson , A. J Bankovich , J. P Pereira , Y Xu , C. M Roots , J. N Beilke , A Banerjee , S. L Reiner , S. A Miller , A. S Weinmann , C. C Goodnow , L. L Lanier , J. G Cyster and J. Chun

During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in blood and spleen but increased in lymph nodes (LNs) and bone marrow (BM). The accumulation of NK cells in LNs reflected a decreased ability to exit into lymph. This strain carries a point mutation within Tbx21 (T-bet), which generates a defective protein. Duane NK cells have a 30-fold deficiency in sphingosine-1-phosphate receptor 5 (S1P5) transcript levels, and S1P5-deficient mice exhibit an egress defect similar to Duane. Chromatin immunoprecipitation confirms binding of T-bet to the S1pr5 locus. S1P-deficient mice exhibit a more severe NK cell egress block, and the FTY720-sensitive S1P1 also plays a role in NK cell egress from LNs. S1P5 is not inhibited by CD69, a property that may facilitate trafficking of activated NK cells to effector sites. Finally, the accumulation of NK cells within BM of S1P-deficient mice was associated with reduced numbers in BM sinusoids, suggesting a role for S1P in BM egress. In summary, these findings identify S1P5 as a T-bet–induced gene that is required for NK cell egress from LNs and BM.

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